A comparative proteinomic analysis of nipple aspiration fluid from healthy women and women with breast cancer
| Autor: | G.R. Coulton, Gerald Gui, Clare M. Isacke, Jillian Noble, R.S. Dua |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Both breasts Biopsy Fine-Needle Mammary gland Breast Neoplasms Pilot Projects Mamelon Breast cancer Cancer risk assessment Biopsy Humans Medicine skin and connective tissue diseases Gynecology medicine.diagnostic_test business.industry Obstetrics Cancer Middle Aged medicine.disease Body Fluids Neoplasm Proteins Treatment Outcome medicine.anatomical_structure Oncology Nipples Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Aspiration fluid Feasibility Studies Female business |
| Zdroj: | European Journal of Cancer. 43:2315-2320 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2007.08.009 |
| Popis: | This pilot study examines the feasibility of nipple aspiration to distinguish women with breast cancer from healthy women using surface-enhanced laser desorption ionisation time-of-flight mass spectrometry (SELDI-TOF/MS). Nipple aspiration fluid (NAF) was collected from each breast in 21 women newly diagnosed with unilateral breast cancer and 44 healthy women. No differences were found when proteomic profiles of NAF from the cancer-bearing breast and the contralateral non-cancerous breast were compared. In contrast, 9 protein peaks were significantly different between the cancer-bearing breast compared with healthy women and 10 peaks were significantly different between the contralateral healthy breast and healthy women (P < 0.05). These data suggest that invasive breast cancer may result in a field change across both breasts and that proteomic profiling of NAF may have more value in breast cancer risk assessment than as a diagnostic or screening tool. |
| Databáze: | OpenAIRE |
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