In vivogastroprotective effect of xyloccensin-E and xyloccensin-I fromXylocarpus molluccensisin rats
| Autor: | Gautam Palit, Vaibhav Mishra, Vijai Lakshmi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Limonins
Male Xylocarpus Plant Science Pharmacology Biochemistry Analytical Chemistry Rats Sprague-Dawley H(+)-K(+)-Exchanging ATPase In vivo Xyloccensin E medicine Animals Stomach Ulcer Meliaceae biology Plant Extracts Chemistry Organic Chemistry Mucin Xyloccensin I Proton Pump Inhibitors Anti-Ulcer Agents biology.organism_classification In vitro Mechanism of action Female medicine.symptom Phytotherapy |
| Zdroj: | Natural Product Research. 29:469-473 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Anti-ulcer activities of xyloccensin-E and xyloccensin-I were investigated in various ulcer models in Sprague-Dawley rats. The effects and the mechanism of action of both compounds for anti-secretory and cytoprotective activities were also studied. Both these active molecules improved the depleted levels of mucin and consequently inhibited the formation of erosions in a pyloric ligated ulcer model. Furthermore, xyloccensin-E and xyloccensin-I inhibited H(+)K(+)-ATPase activity in vitro confirming their anti-secretory activity. In conclusion, xyloccensin-E and xyloccensin-I were found to possess anti-ulcerogenic activity which might be due to their anti-secretory activity and subsequent strengthening of the defensive mechanism. |
| Databáze: | OpenAIRE |
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