Carcinosarcomas (Malignant Mullerian Mixed Tumors) of the Uterus and Ovary: A Genetic Study With Special Reference to Histogenesis
| Autor: | Gen Tamura, Shin-ya Ogata, Yousei Katayama, Masayuki Fukase, Zhe Jin, Teiichi Motoyama, Mihoko Yajima |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Pathology medicine.medical_specialty DNA Mutational Analysis Uterus Loss of Heterozygosity Mixed Tumor Mullerian Ovary Histogenesis Biology Polymerase Chain Reaction Pathology and Forensic Medicine medicine Humans Gene Silencing Ovarian Carcinosarcoma Aged Ovarian Neoplasms Chromosomes Human X Mixed tumor Obstetrics and Gynecology Middle Aged Genes p53 medicine.disease Immunohistochemistry Genes ras medicine.anatomical_structure Mutation Uterine Neoplasms Monoclonal Female Spindle cell carcinoma Microsatellite Repeats |
| Zdroj: | International Journal of Gynecological Pathology. 22:368-373 |
| ISSN: | 0277-1691 |
| DOI: | 10.1097/01.pgp.0000092134.88121.56 |
| Popis: | The histogenesis of carcinosarcomas (malignant mullerian mixed tumors) of the female genital tract is still not completely understood. In the present study, several different molecular pathologic techniques were applied to determine the histogenesis of 15 uterine and ovarian carcinosarcomas. The patterns of X-chromosome inactivation and the presence of p53 and K-ras mutations were analyzed in the carcinomatous and sarcomatous components. Microsatellite analysis was also performed. Ten tumors were monoclonal, one was biclonal (collision tumor), and another was probably biclonal; the other three were of indeterminate histogenesis. These data indicate that most uterine and ovarian carcinosarcomas are monoclonal. |
| Databáze: | OpenAIRE |
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