Validating hyperbilirubinemia and gut mucosal atrophy with a novel ultramobile ambulatory total parenteral nutrition piglet model
| Autor: | Jonathan Rodrigues, Jeffery H. Teckman, John P. Long, Timothy A. Blaufuss, Victor Liou, Keith Blomenkamp, Joy X. Wen, Douglas G. Burrin, Sumit Arora, Ajay Jain |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Swine Endocrinology Diabetes and Metabolism Mucosal atrophy Weight Gain Gastroenterology Enteral Nutrition Endocrinology Atrophy Cholestasis Internal medicine Jugular vein medicine Animals Intestinal Mucosa Infusions Intravenous Hyperbilirubinemia Nutrition and Dietetics business.industry Drug Administration Routes Body Weight medicine.disease Catheter Treatment Outcome Parenteral nutrition Animals Newborn Liver Ambulatory Parenteral Nutrition Total medicine.symptom business Weight gain |
| Zdroj: | Nutrition Research. 35:169-174 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2014.12.004 |
| Popis: | Total parenteral nutrition (TPN) provides all nutrition intravenously. Although TPN therapy has grown enormously, it causes significant complications, including gut and hepatic dysfunction. Current models use animal tethering which is unlike ambulatory human TPN delivery and is cost prohibitive. We hypothesize that using ultramobile infusion pumps, TPN can be delivered cost-effectively, resulting in classical gut and hepatic injury, and we thus aim to establish a new model system. Neonatal pigs (n=8) were implanted with jugular vein and duodenal catheters. Animals were fitted in dual-pocket jackets. An ultramobile ambulatory pump was placed in one pocket and connected to the jugular vein or duodenal catheter. Isocaloric TPN or swine formula was placed in the other pocket. Rigorous Wifi-based video and scheduled monitoring was performed. After 14days, the animals were euthanized. The mean (±SD) daily weight gain (in grams) for enteral-fed control (EN) vs TPN animals was 102.4±10.8 and 91.03±12.1 respectively (P |
| Databáze: | OpenAIRE |
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