Distribution of Radioactivity in Bone and Related Structures following Administration of [14C]Dalbavancin to New Zealand White Rabbits▿

Autor:	Bharat Damle, Jonghui Lee, Eric G. Solon, S. Peter King, James A. Dowell
Jazyk:	angličtina
Rok vydání:	2007
Předmět:	Male medicine.medical_specialty medicine.drug_class Antibiotics Physiology Connective tissue Microbial Sensitivity Tests Gram-Positive Bacteria Bone and Bones Pharmacokinetics Bone Marrow medicine Animals Pharmacology (medical) Experimental Therapeutics Tissue Distribution Carbon Radioisotopes Antibacterial agent Pharmacology Lagomorpha biology Dalbavancin biology.organism_classification Surgery Anti-Bacterial Agents Infectious Diseases medicine.anatomical_structure Connective tissue metabolism Connective Tissue Autoradiography Joints Bone marrow Rabbits Teicoplanin
Popis:	Penetration of dalbavancin into noninfected bone and joint tissues was assessed after an intravenous dose of 20 mg/kg (of body weight) [ 14 C]dalbavancin given to rabbits. Drug-derived radioactivity, determined over 14 days by either liquid scintillation counting or autoradiography, remained above the MIC for common gram-positive pathogens that cause bone and joint infections.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba38346438416ec1c3511b3fe0b2118 https://europepmc.org/articles/PMC1932505/ Zobrazit plný text záznamu