Assessment of the Efficacy of Platelet-Rich Plasma in the Treatment of Traumatic Canine Fractures

Autor: Joaquin Sopena, José M. Carrillo, And Mónica Rubio, Deborah Chicharro, Jose M. Vilar, Sergio López, Elena Damiá, Belén Cuervo
Přispěvatelé: Producción Científica UCH 2019, UCH. Departamento de Medicina y Cirugía Animal
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
External Fixators
Carprofen
medicine.medical_treatment
Dentistry
Palpation
lcsh:Chemistry
0403 veterinary science
Fractures
Bone
Random Allocation
Medicine
Crecimiento - Factores - Uso terapéutico
lcsh:QH301-705.5
Saline
Spectroscopy
Fracture Healing
Growth factors - Therapeutic use
medicine.diagnostic_test
Platelet-Rich Plasma
Dogs - Wounds and injuries - Treatment
Perros - Heridas y lesiones - Tratamiento
04 agricultural and veterinary sciences
General Medicine
Computer Science Applications
medicine.anatomical_structure
dog
Intercellular Signaling Peptides and Proteins
Female
Plasma sanguíneo - Uso terapéutico
bone healing
Blood plasma - Therapeutic use
medicine.drug
040301 veterinary sciences
Physical examination
Bone healing
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
Dogs
Animals
Tibia
Physical and Theoretical Chemistry
Molecular Biology
PRGF
business.industry
Organic Chemistry
Ulna
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
fracture
Platelet-rich plasma
business
Zdroj: International Journal of Molecular Sciences
Volume 20
Issue 5
CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1075 (2019)
ISSN: 1422-0067
DOI: 10.3390/ijms20051075
Popis: Este es el artículo que se ha publicado de forma definitiva en: https://www.mdpi.com/1422-0067/20/5/1075 The role of platelet-rich plasma (PRP) in promoting the healing of bone fractures has notyet been clearly stated. The aim of this prospective clinical study was to evaluate the effectiveness ofplasma rich in growth factors (PRGF, a PRP derivate) in the treatment of naturally-occurring bonefractures in dogs. With this objective, sixty-five dogs with radius/ulna or tibia/fibula bone fractureswere randomly divided into two groups (PRGF and saline solution (SS) groups) and checked atdays 0, 7, 14, 21, 28, 35, 42, 49, 56, 60, 63, 70, 120, and 180. All the fractures were treated with anexternal skeletal fixation, and pain was controlled with Carprofen. Healing was evaluated by physicalexamination, limb function, radiography, and by a Likert-type owner satisfaction questionnaire.A faster fracture healing was observed in the PRGF group, with statistically significant differenceswith respect to the SS group. Swelling at the fracture site was significantly greater at day 14 and28 in animals injected with PRGF, and more pain on palpation was found in the area at day 28.The injection of PRGF in acute bone fractures accelerates bone healing.
Databáze: OpenAIRE
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