The effects of adjuvant experimental radioimmunotherapy and hyperthermic intraperitoneal chemotherapy on intestinal and abdominal healing after cytoreductive surgery for peritoneal carcinomatosis in the rat

Autor: Robert P. Bleichrodt, O.C. Boerman, Frits Aarts, Thijs Hendriks, Roger M. L. M. Lomme, B.M. de Man
Rok vydání: 2008
Předmět:
Male
medicine.medical_treatment
Aetiology
screening and detection [ONCOL 5]
Lutetium
Abdominal wall
Immune Regulation [NCMLS 2]
Peritoneal Neoplasms
Antibiotics
Antineoplastic
Anastomosis
Surgical
Combined Modality Therapy
Pathogenesis and modulation of inflammation [N4i 1]
Intestines
Survival Rate
Hydroxyproline
medicine.anatomical_structure
Treatment Outcome
Oncology
Gelatinases
Radioimmunotherapy
Colonic Neoplasms
Hyperthermic intraperitoneal chemotherapy
Perfusion
Injections
Intraperitoneal
Hyperthermia
medicine.medical_specialty
Mitomycin
Urology
Anastomosis
Translational research [ONCOL 3]
medicine
Animals
Survival rate
Chemotherapy
Wound Healing
business.industry
Abdominal Wall
Immunotherapy
gene therapy and transplantation [UMCN 1.4]
Rats
Inbred Strains
Hyperthermia
Induced
medicine.disease
Surgery
Rats
Disease Models
Animal
Evaluation of complex medical interventions [NCEBP 2]
Chemotherapy
Cancer
Regional Perfusion
Functional Imaging [UMCN 1.1]
business
Immunity
infection and tissue repair [NCMLS 1]
Zdroj: Annals of Surgical Oncology, 15, 3299-307
Annals of Surgical Oncology, 15, 11, pp. 3299-307
ISSN: 1068-9265
Popis: Contains fulltext : 70763.pdf (Publisher’s version ) (Closed access) BACKGROUND: Cytoreductive surgery (CS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) results in limited survival benefit and high morbidity and mortality rates in patients with peritoneal carcinomatosis (PC). Radioimmunotherapy (RIT) after CS of experimental PC has been shown to increase survival and compare favorably to HIPEC. The effects of RIT and HIPEC on wound healing after CS need to be determined. METHODS: PC was induced by intraperitoneal inoculation of CC-531 colon carcinoma cells in Wag/Rij rats. Animals were subjected to CS and anastomotic construction only or followed by RIT or HIPEC. RIT consisted of 74 MBq (177)lutetium-labeled anti-CC531 antibody MG1. HIPEC was performed by a closed abdominal perfusion technique using mitomycin-C during 60 minutes. Anastomotic and abdominal wall strength measurements were performed 3 and 5 days after surgery. RESULTS: At day 5, bursting pressure in ileum and colon anastomoses in the CS + HIPEC group, but not in the CS + RIT group, was lower (P < .01) than in the CS group. In the CS group, the colonic bursting site was more often outside the true anastomotic area (8 of 12 animals) than in the CS + HIPEC (1 of 12) and CS + RIT (5 of 12) groups. Abdominal wall strength in the CS + HIPEC group was significantly (P < .01) lower, at both measuring points, than that in both the CS group and the CS + RIT group. There was no difference between the latter. CONCLUSION: As adjuvant to CS, HIPEC showed a decrease in anastomotic and abdominal wall wound strength in a model of PC of CRC, whereas RIT did not.
Databáze: OpenAIRE
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