Diabetes Mellitus: An Independent Risk Factor of In-Hospital Mortality in Patients with Infective Endocarditis in a New Era of Clinical Practice
| Autor: | Chi-Ling Hang, Sheng-Ying Chung, Cheng-Jei Lin, Sarah Chua, Tzu-Hsien Tsai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Health Toxicology and Mutagenesis lcsh:Medicine macromolecular substances 030204 cardiovascular system & hematology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Risk of mortality Medicine Humans 030212 general & internal medicine Hospital Mortality Risk factor Aged Creatinine Endocarditis business.industry infective endocarditis Incidence (epidemiology) Mortality rate musculoskeletal neural and ocular physiology Incidence lcsh:R Public Health Environmental and Occupational Health Middle Aged Staphylococcal Infections medicine.disease Prognosis mortality chemistry nervous system Infective endocarditis diabetes mellitus Observational study Female business |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 16, Iss 12, p 2248 (2019) Volume 16 Issue 12 |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | Infective endocarditis (IE) is a severe disease with a hospital mortality rate of 17&ndash 25%. Early identification of IE patients with high risk of mortality may improve their clinical outcomes. Patients with diabetes mellitus (DM) who develop infective diseases are associated with worse outcomes. This study aimed to define the impact of DM on long-term mortality in IE patients. A total of 412 patients with definite IE from February 1999 to June 2012 were enrolled in this observational study and divided into 2 groups: group 1, patients with DM (n = 72) and group 2, patients without DM (n = 340). The overall in-hospital mortality rate for both groups combined was 20.2% and was higher in group 1 than in group 2 (41.7% vs. 16.5%, p < 0.01). Compared to patients without DM, patients with DM were older and associated with higher incidence of chronic diseases, less drug abuse, higher creatinine levels, and increased risk of Staphylococcus aureus infection (all p < 0.05). Moreover, they were more likely to have atypical clinical presentation and were associated with longer IE diagnosis time (all p < 0.05). In multivariable analysis, DM is an independent and significant predictor of mortality. The prognosis of IE patients with DM is still poor. Early identification and more aggressive treatment may be considered in IE patients with DM. |
| Databáze: | OpenAIRE |
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