Effects of physical exercise on spatial memory and astroglial alterations in the hippocampus of diabetic rats

Autor: Carlos Alberto Gonçalves, Mariana Fontoura Paim, Jocemar Ilha, Pedro Porto Alegre Baptista, Matilde Achaval, Léder Leal Xavier, Priscylla Nunes de Senna, Patrícia Severo do Nascimento, Marina Concli Leite
Rok vydání: 2011
Předmět:
Zdroj: Metabolic Brain Disease. 26:269-279
ISSN: 1573-7365
0885-7490
DOI: 10.1007/s11011-011-9262-x
Popis: Type 1 diabetes mellitus (T1DM) is associated with neurocognitive dysfunction and astrogliosis. Physical exercise prevents cognitive impairments and induces important brain modifications. The aim of our study was to investigate the effect of treadmill exercise on spatial memory and astrocytic function in the hippocampus of a T1DM model. Fifty-seven Wistar rats were divided into four groups: trained control (TC) (n = 15), non-trained control (NTC) (n = 13), trained diabetic (TD) (n = 14) and non-trained diabetic (NTD) (n = 15). One month after streptozotocin-induced diabetes, exercise groups were submitted to 5 weeks of physical training, and then, all groups were assessed in the novel object-placement recognition task. Locomotor activity was analyzed in the open field apparatus using Any-maze software. The expression of glial fibrillary acidic protein (GFAP) and S100B in hippocampus and cerebrospinal fluid were measured using ELISA assay, and hippocampal GFAP immunoreactivity was evaluated by means of immunohistochemistry and optical densitometry. The results showed that physical exercise prevents and/or reverts spatial memory impairments observed in NTD animals (P
Databáze: OpenAIRE
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