Temporal changes in whole-blood and plasma glutathione in ICU patients with multiple organ failure
| Autor: | Jan Wernerman, Urban Fläring, Olav Rooyackers, Christina Hebert, T. Bratel, Folke Hammarqvist |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Icu patients medicine.medical_specialty Pathology Resuscitation Time Factors Critical Care Critical Illness Multiple Organ Failure Pilot Projects Critical Care and Intensive Care Medicine medicine.disease_cause chemistry.chemical_compound Anesthesiology Intensive care Internal medicine medicine Humans Prospective Studies skin and connective tissue diseases Whole blood Aged business.industry Respiratory disease Glutathione Middle Aged medicine.disease Intensive Care Units chemistry Cardiology Female sense organs business Oxidative stress |
| Zdroj: | Intensive care medicine. 31(8) |
| ISSN: | 0342-4642 |
| Popis: | This study investigated the temporal changes in whole-blood and plasma glutathione in ICU patients with multiple organ failure.Prospective and descriptive pilot study performed in an ICU with eight beds at a university hospital.Critically ill patients (n=11) with multiple organ failure and ICU stay of at least 6 days were consecutively included. Patients with chronic obstructive pulmonary disease (n=21) and healthy volunteers (n=10) were used as reference groups.Whole-blood and plasma glutathione were measured every 72 h. Total glutathione and the reduced fraction were determined in whole blood. The oxidized fraction and the redox status were calculated from these values. In plasma only the total concentration was determined. Patients were studied for 6-15 days. Nutrition was supplied according to routines supplying basal needs including glutamine. Both total and reduced glutathione was found to be depleted in whole blood compared to the reference groups. Redox status indicated continuing oxidative stress. Plasma glutathione showed higher values in total concentrations than the reference groups.This study demonstrates that glutathione remains depleted in whole blood. This contrasts to what has previously been shown in skeletal muscle where a restitution of glutathione concentration is seen. |
| Databáze: | OpenAIRE |
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