Dental staining after doxycycline use in children
| Autor: | Ville Peltola, Heidi Pöyhönen, Olli Ruuskanen, Mirka Nurmi, Tuire Lähdesmäki, Satu Alaluusua |
|---|---|
| Přispěvatelé: | Clinicum, University of Helsinki, Department of Oral and Maxillofacial Diseases, HUS Head and Neck Center |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male YOUNG-CHILDREN medicine.drug_class 030106 microbiology Antibiotics Dentistry LYME NEUROBORRELIOSIS Medical Records 03 medical and health sciences TEETH 0302 clinical medicine stomatognathic system 030225 pediatrics TETRACYCLINES medicine Humans Pharmacology (medical) Child Permanent teeth Original Research Pharmacology Doxycycline Dental Enamel Hypoplasia ta313 Enamel paint business.industry Infant Enamel hypoplasia medicine.disease ta3123 Hypoplasia 3. Good health Staining Anti-Bacterial Agents stomatognathic diseases Infectious Diseases 317 Pharmacy visual_art 3121 General medicine internal medicine and other clinical medicine Child Preschool visual_art.visual_art_medium Tooth Discoloration Female business Tooth medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy |
| ISSN: | 0305-7453 |
| Popis: | Background: The use of doxycycline has been avoided before 8 years of age due to known dental staining caused by tetracyclines, although doxycycline differs from classical tetracyclines in many ways. Doxycycline is still an important antimicrobial agent, but its dental safety is not well studied. Objectives: To examine the state of permanent teeth after doxycycline exposure in children,8 years of age. Methods: Details of doxycycline treatment were collected from medical records. After the eruption of permanent teeth the dental status was examined by an experienced paediatric dentist for detection of dental staining and enamel hypoplasia. The resulting dental photographs were evaluated by a second independent experienced paediatric dentist. Results: The mean age of 38 study subjects at the time of doxycycline treatment was 4.7 years (range 0.6-7.9 years, SD 2.3). The doxycycline dose was 10 mg/kg/day (varying from 8 to 10 mg/kg/day) for the first 2-3 days and 5mg/kg/day (varying from 2.5 to 10mg/kg/day) thereafter. The mean length of the treatment was 12.5days (SD 6.0) and ranged from 2 to 28 days. Tetracycline-like staining or enamel hypoplasia of developing teeth was detected in none of the subjects. Conclusions: Doxycycline treatment of small children does not seem to induce permanent tooth staining. |
| Databáze: | OpenAIRE |
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