EFFICACY OF DIFFERENT TACTICS FOR INITIAL ANTIHYPERTENSIVE THERAPY
| Autor: | A. O. Konrady, O. A. Pleyko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Drug
монотерапия arterial hypertension medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system media_common.quotation_subject RM1-950 combined therapy Hydrochlorothiazide Fosinopril Internal medicine Diseases of the circulatory (Cardiovascular) system Medicine Pharmacology (medical) Amlodipine комбинированная терапия media_common business.industry Indapamide lcsh:RM1-950 артериальная гипертензия Rilmenidine Surgery Blood pressure lcsh:Therapeutics. Pharmacology Bisoprolol lcsh:RC666-701 monotherapy RC666-701 Therapeutics. Pharmacology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 3, Iss 1, Pp 21-27 (2015) |
| ISSN: | 2225-3653 1819-6446 |
| Popis: | Aim. To evaluate different tactics of initial antihypertensive therapy.Material and Methods. 120 patients with mild-to-moderate arterial hypertension were included and randomized into three groups: “A”, “B”, and “C”. 5 drugs from the main antihypertensive classes were used: indapamide, bisoprolol, amlodipine, fosinopril, and rilmenidine as well as fixed drug combination of fosinopril and hydrochlorothiazide. Patients included in group “A” received initial therapy according to individual leading pathogenic variant of hypertension. Patients from group “B” received standard stepped antihypertensive therapy with gradual dose increase and further addition of second (third) drug. Patients in group “C” were immediately administrated fixed drug combination and later added other drugs. Visits were scheduled after 2, 4, 6, 8, 10, etc weeks of treatment up to achievement of target blood pressure (BP).Results. In group “A” 33 patients (82,5%) achieved target BP after 6 visits, in group “B” - 37 patients (92,5%) after 8 visits and in group “C” - 100% of patents after 6 visits. Thus, in group “C” there was less number of visits and respectively lower number of therapy changes in order to achieve target BP. No significant discrepancies between group “A” and “B” were observed.Conclusion. Tactics of initial antihypertensive therapy with usage of fixed drug combination results in more effective and fast achievement of target BP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|