Development of metabolic alkalosis after massive transfusion during orthotopic liver transplantation
| Autor: | Sheldon Randall, George L. Blackburn, Benjamin Gerson, Walter H. Dzik, Roger L. Jenkins, David F. Driscoll, Bruce R. Bistrian |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Blood transfusion Alkalosis medicine.medical_treatment Metabolic alkalosis Acid-Base Imbalance Liver transplantation Critical Care and Intensive Care Medicine Postoperative Complications medicine Humans Citrates Acidosis business.industry Transfusion Reaction Metabolic acidosis Hydrogen-Ion Concentration medicine.disease Liver Transplantation Surgery Anesthesia Blood Gas Analysis medicine.symptom Complication business Acid–base imbalance |
| Zdroj: | Critical Care Medicine. 15:905-908 |
| ISSN: | 0090-3493 |
| Popis: | Five patients undergoing orthotopic liver transplantation were investigated for changes in acid-base homeostasis secondary to large volume transfusions. All patients developed a transient acidemia during the operative period, followed by alkalemia which persisted into the early postoperative period. The patients received an estimated mean of 750 mEq of citrate, which appeared to cause metabolic alkalosis. The biochemical basis underlying the regulation of citrate metabolism that may have led to the timing, extent, and duration of the subsequent metabolic alkalosis is presented. Finally, the time course for the development of metabolic alkalosis may be a potentially sensitive indicator of early allograft function. |
| Databáze: | OpenAIRE |
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