Differentiation of high-grade and low-grade intra-axial brain tumors by time-dependent diffusion MRI
| Autor: | Akihiko Wada, Saori Koshino, Tomoko Maekawa, Akifumi Hagiwara, Kouhei Kamiya, Toshiaki Akashi, Christina Andica, Thorsten Feiweier, Shigeki Aoki, Osamu Abe, Koji Kamagata, Katsutoshi Murata, Masaaki Hori, Shohei Fujita |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Time Factors Biomedical Engineering Biophysics Brain tumor 030218 nuclear medicine & medical imaging Diagnosis Differential White matter 03 medical and health sciences 0302 clinical medicine Region of interest medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Grading (tumors) Aged medicine.diagnostic_test Brain Neoplasms business.industry Subtraction Magnetic resonance imaging Middle Aged medicine.disease body regions Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Female Neoplasm Grading Nuclear medicine business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Magnetic Resonance Imaging. 72:34-41 |
| ISSN: | 0730-725X |
| Popis: | Introduction Oscillating gradient spin-echo (OGSE) sequences enable acquisitions with shorter diffusion times. There is growing interest in the effect of diffusion time on apparent diffusion coefficient (ADC) values in patients with cancer. However, little evidence exists regarding its usefulness for differentiating between high-grade and low-grade brain tumors. The purpose of this study is to investigate the utility of changes in the ADC value between short and long diffusion times in distinguishing low-grade and high-grade brain tumors. Material and methods Eleven patients with high-grade brain tumors and ten patients with low-grade brain tumors were scanned using a 3 T magnetic resonance imaging with diffusion-weighted imaging (DWI) using OGSE and PGSE (effective diffusion time [Δeff]: 6.5 ms and 35.2 ms) and b-values of 0 and 1000 s/mm2. Using a region of interest (ROI) analysis of the brain tumors, we measured the ADC for two Δeff (ADCΔeff) values and computed the subtraction ADC (ΔADC = ADC6.5 ms − ADC35.2 ms) and the relative ADC (ΔADC = (ADC6.5 ms − ADC35.2 ms) / ADC35.2 ms × 100). The maximum values for the subtraction ADC (ΔADCmax) and the relative ADC (rADCmax) on the ROI were compared between low-grade and high-grade tumors using the Wilcoxon rank-sum test. A P-value Results High-grade tumors had significantly higher ΔADCmax and rADCmax than low-grade tumors. The ΔADCmax values of the normal white matter were lower than the ΔADCmax of high- and low-grade brain tumors. Conclusion The dependence of ADC values on diffusion time between 6.5 ms and 35.2 ms was stronger in high-grade tumors than in low-grade tumors, suggesting differences in internal tissue structure. This finding highlights the importance of reporting diffusion times in ADC evaluations and might contribute to the grading of brain tumors using DWI. |
| Databáze: | OpenAIRE |
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