Tandem Cyclization of α-Cyano α-Alkynyl Aryl Ketones Induced by tert-Butyl Hydroperoxide and Tetrabutylammonium Iodide
| Autor: | Yu‐Cheng Yeh, Ying-Chieh Wong, Chen-Tso Tseng, Kak-Shan Shia, Tzu-Ting Kao |
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| Rok vydání: | 2012 |
| Předmět: |
Molecular Structure
Tandem Chemistry Aryl Organic Chemistry Stereoisomerism Ketones Tetrabutylammonium iodide Biochemistry Medicinal chemistry Catalysis Quaternary Ammonium Compounds chemistry.chemical_compound tert-Butylhydroperoxide Cyclization Alkynes tert-Butyl hydroperoxide Combinatorial Chemistry Techniques Organic chemistry Hydrocarbons Iodinated Physical and Theoretical Chemistry Benzene |
| Zdroj: | Organic Letters. 14:6024-6027 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol3028972 |
| Popis: | The radical cascade protocol of the α-cyano α-TMS/aryl-capped alkynyl aryl ketones promoted by tert-butyl hydroperoxide under catalysis with tetrabutylammonium iodide in refluxing benzene has been developed, leading to the construction of a variety of highly functionalized [6,6,5] tricyclic frameworks in an efficient manner. |
| Databáze: | OpenAIRE |
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