Yellow-colored extract from cashew byproduct - Nonclinical safety assessment
| Autor: | Ana Lúcia Tasca Gois Ruiz, Lucia Elaine de Oliveira Braga, Sirlene Valério Tinti, Gisele Goulart da Silva, Adriana Della Torre, Patricia Bachiega, João Carvalho, Ana Paula Dionísio |
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| Rok vydání: | 2020 |
| Předmět: |
Erythrocytes
Administration Oral Color CHO Cells 010501 environmental sciences Toxicology 030226 pharmacology & pharmacy 01 natural sciences 03 medical and health sciences Mice 0302 clinical medicine Cricetulus Antimutagenic Effect In vivo Toxicity Tests Acute Animals Anacardium Oral toxicity Food science Coloring Agents Carotenoid 0105 earth and related environmental sciences chemistry.chemical_classification SUBPRODUTOS COMO ALIMENTO Mutagenicity Tests Plant Extracts Nonclinical safety General Medicine Toxicity Tests Subacute chemistry Micronucleus test Female Natural dye |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1096-0295 |
| Popis: | Natural and synthetic dyes are widely used in foodstuff, medicines and cosmetics industries to enhance and/or restore the color of the final products. This study aimed to evaluate the safety of oral consumption of one carotenoids and anacardic acids-enriched extract (CAE), obtained by green extraction from cashew apple residue fibers, a byproduct of the cashew juice industry. Presenting intense yellow color, CAE could be proposed as a new natural dye. Single and repeated-dose oral toxicity (30 days) were evaluated in female Swiss mice at doses ranging from 50 to 1000 mg/kg, while (anti)mutagenic effects were evaluated in CHO–K1 cells (in vitro Cytokinesis-Block Micronucleus assay - CBMN) and in erythrocytes collected from murine bone marrow (in vivo). CAE did not induce toxic or mutagenic effects in female mice even after 30 days of treatment, regardless of the dose used. Considering cyclophosphamide (CPA)-challenged animals treated with CAE, neither antimutagenic effect was observed nor CAE increased CPA-mutagenic effects although in vitro CBMN results indicated that CAE might increase methyl methanesulfonate-induced micronuclei (MN) frequency besides promoting reduction on CPA-induced MN frequency. The obtained results suggest that CAE may be a safe source of carotenoids with potential use as industrial dye. |
| Databáze: | OpenAIRE |
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