Procalcitonin as a potent marker of bacterial infection in febrile Afro-Caribbean patients at the emergency department
| Autor: | Maarten Limper, M. D. de Kruif, A. P. van Zanten, Ashley J. Duits, Dees P. M. Brandjes, N. E. Ajubi, E. C. M. van Gorp |
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| Přispěvatelé: | Virology |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Calcitonin Male Microbiology (medical) Emergency Medical Services medicine.medical_specialty medicine.drug_class Calcitonin Gene-Related Peptide Antibiotics Population Black People Sensitivity and Specificity Gastroenterology Article Procalcitonin Medical microbiology Internal medicine medicine Humans Prospective Studies Protein Precursors Prospective cohort study education Aged education.field_of_study biology business.industry C-reactive protein Area under the curve Bacterial Infections General Medicine Emergency department Middle Aged Surgery C-Reactive Protein Infectious Diseases Caribbean Region biology.protein Female business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases, 30(7), 831-836. Springer-Verlag European Journal of Clinical Microbiology & Infectious Diseases |
| ISSN: | 1435-4373 0934-9723 |
| Popis: | Procalcitonin (PCT) has been shown to be of additional value in the work-up of a febrile patient. This study is the first to investigate the additional value of PCT in an Afro-Caribbean febrile population at the emergency department (ED) of a general hospital. Febrile patients were included at the ED. Prospective, blinded PCT measurements were performed in patients with a microbiologically or serologically confirmed diagnosis or a strongly suspected diagnosis on clinical grounds. PCT analysis was performed in 93 patients. PCT levels differentiated well between confirmed bacterial and confirmed viral infection (area under the curve [AUC] of 0.82, sensitivity 85%, specificity 69%, cut-off 0.24 ng/mL), between confirmed bacterial infection and non-infectious fever (AUC of 0.84, sensitivity 90%, specificity 71%, cut-off 0.21 ng/mL) and between all bacterial infections (confirmed and suspected) and non-infectious fever (AUC of 0.80, sensitivity 85%, specificity 71%, cut-off 0.21 ng/mL). C-reactive protein (CRP) levels were shown to be less accurate when comparing the same groups. This is the first study showing that, in a non-Caucasian febrile population at the ED, PCT is a more valuable marker of bacterial infection than CRP. These results may improve diagnostics and eventually decrease antibiotic prescriptions in resource-limited settings. |
| Databáze: | OpenAIRE |
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