SOD mimics: From the tool box of the chemists to cellular studies
| Autor: | Clotilde Policar, Jean Bouvet, Hélène C. Bertrand, Nicolas Delsuc |
|---|---|
| Přispěvatelé: | Laboratoire des biomolécules (LBM UMR 7203), Chimie Moléculaire de Paris Centre (FR 2769), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département de Chimie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL), Sorbonne Université (SU), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), Université de Bordeaux (UB)-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Policar, Clotilde |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
[CHIM.INOR] Chemical Sciences/Inorganic chemistry
Superoxide Dismutase [CHIM.ORGA]Chemical Sciences/Organic chemistry [CHIM.INOR]Chemical Sciences/Inorganic chemistry [CHIM.COOR] Chemical Sciences/Coordination chemistry [CHIM.ORGA] Chemical Sciences/Organic chemistry Biochemistry Catalysis Analytical Chemistry Cellular studies Design of metallodrugs Biomimetic Materials Coordination Complexes Superoxides [CHIM.OTHE] Chemical Sciences/Other Metalloproteins SOD mimics or mimetics [CHIM.COOR]Chemical Sciences/Coordination chemistry X-fluorescence imaging or X-fluorescence microscopy XFM [CHIM.OTHE]Chemical Sciences/Other |
| Zdroj: | Current Opinion in Chemical Biology Current Opinion in Chemical Biology, 2022, 67, pp.102109. ⟨10.1016/j.cbpa.2021.102109⟩ |
| ISSN: | 1367-5931 |
| Popis: | International audience; Superoxide dismutases (SODs) are metalloproteins that protect cells against oxidative stress by controlling the concentration of superoxide (O2-) through catalysis of its dismutation. The activity of superoxide dismutases can be mimicked by low-molecular-weight complexes having potential therapeutic applications. This review presents recent strategies for designing efficient SOD mimics, from molecular metal complexes to nanomaterials. Studies of these systems in cells reveal that some SOD mimics, designed to react directly with superoxide, may also indirectly enhance the cellular antioxidant arsenal. Finally, a good understanding of the bioactivity requires information on the cell-penetration, speciation, and subcellular location of the SOD mimics: we will describe recent studies and new techniques that open opportunities for characterizing SOD mimics in biological environments. |
| Databáze: | OpenAIRE |
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