Reducing shock imminence eliminates poor avoidance in rats
| Autor: | Robert M. Sears, Danielle M. Moloney, Christopher K. Cain, Shanna B. Samels, Lindsay C. Laughlin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Coping (psychology) Psychotherapist Time Factors Cognitive Neuroscience Conditioning Classical Brief Communication Task (project management) Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Adaptation Psychological medicine Avoidance Learning Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Behavior Animal 05 social sciences Rats Neuropsychology and Physiological Psychology Harm Maladaptive coping Shock (circulatory) Anxiety Conditioning Operant Instrumental learning Female medicine.symptom Psychology 030217 neurology & neurosurgery Psychomotor Performance Cognitive psychology |
| Zdroj: | Learn Mem |
| DOI: | 10.1101/2020.01.30.927152 |
| Popis: | In the signaled active avoidance (SigAA) paradigm, rats learn to suppress Pavlovian reactions (e.g. freezing) and emit instrumental actions (e.g. shuttling) to escape threats and prevent pain. This paradigm is critical for understanding aversively-motivated instrumental learning and both maladaptive and adaptive coping strategies in human anxiety. However, with standard protocols approximately 25% of rats exhibit high freezing and never master the task (poor avoiders). This has dampened enthusiasm for the paradigm and stalled progress. Here we demonstrate that lowering shock imminence with long-duration warning signals leads to greater freezing suppression and perfect avoidance in all subjects. This suggests that instrumental SigAA mechanisms evolved to cope with temporally distant/uncertain harm and standard protocols that promote inflexible Pavlovian reactions are poorly-designed to study avoidance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|