Testosterone-Binding Levels in the Serum of Women During the Normal Menstrual Cycle, Pregnancy, and the Post-partum Period
| Autor: | Marilyn Murphy, Odette Crépy, William H. Pearlman |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment media_common.quotation_subject Clinical Biochemistry Endogeny In Vitro Techniques Ethinyl Estradiol Tritium Biochemistry Prostate cancer Endocrinology Sex hormone-binding globulin Pregnancy Internal medicine medicine Humans Testosterone Menstrual cycle media_common biology business.industry Postpartum Period Biochemistry (medical) Prostatic Neoplasms Blood Proteins medicine.disease Menstruation Cortisone Estrogen biology.protein Prednisone Female Hemodialysis business Dialysis Chlorotrianisene Protein Binding |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 27:1012-1018 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-27-7-1012 |
| Popis: | The testosterone-binding level (or activity) in human serum, as determined by our technique based on the principle of equilibrium dialysis but utilizing Sephadex G-25, remained low and relatively constant during the normal menstrual cycle. It rose steeply, however, during the first trimester of pregnancy and gradually thereafter, attaining at term a level about 2–3 times that obtained in the nonpregnant state; a rapid return to nonpregnancy levels occurred after delivery. These observations suggest that the testosterone-binding level is directly related to endogenous steroid sex hormone production; estrogen may be particularly important in this respect since elevated testosterone-binding levels were also observed in men with prostatic cancer receiving estrogen therapy. |
| Databáze: | OpenAIRE |
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