Diterpenoid alkaloids from the whole plant of Aconitum tanguticum (Maxim.) Stapf
| Autor: | Zhuju Wang, Li-Mei Lin, Chun Li, Lihua Yang, Shan-shan Guo, Xiaorui Fan, Zhi-Min Wang, Feng Sui, Zi-Han Liu |
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| Rok vydání: | 2019 |
| Předmět: |
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Molecular 0106 biological sciences Aconitum tanguticum Molecular Conformation Ranunculaceae Plant Science Horticulture 01 natural sciences Biochemistry chemistry.chemical_compound Alkaloids Amide Ic50 values Molecular Biology Inhibitory effect Aconitum Traditional medicine biology 010405 organic chemistry Chemistry Influenza a General Medicine biology.organism_classification Terpenoid 0104 chemical sciences Diterpenes 010606 plant biology & botany |
| Zdroj: | Phytochemistry. 160:71-77 |
| ISSN: | 0031-9422 |
| Popis: | Five undescribed diterpenoid alkaloids tanguticulines A-E and two undescribed amide compounds 5-methoxy-N-Salicylanthranilic acid methyl ester and 3, 5-dimethoxy-4- hydroxycinnamamide-4-O-β-D-glucopyranoside, were isolated from the whole plant of Aconitum tanguticum (Maxim.) Stapf. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. Compounds 1 and 5 were evaluated for their antivirus activities against influenza a (H1N1) virus in vitro. Both of them showed obvious inhibitory effect on the cytopathic changes induced by H1N1, with IC50 values of 2.9 μg mL−1 and 2.4 μg mL−1, respectively. |
| Databáze: | OpenAIRE |
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