Complexation of europium(iii ) with exopolysaccharides from a marine bacterium envisaged as luminescent probe in a theranostic approach
| Autor: | Pascal E. Reiller, Cyrille Alliot, Mattia Mazza, Sandrine Huclier-Markai |
|---|---|
| Přispěvatelé: | Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), GIP ARRONAX, Université de Nantes (UN), CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique) |
| Rok vydání: | 2021 |
| Předmět: |
Inorganic chemistry
Ionic bonding chemistry.chemical_element 010402 general chemistry 01 natural sciences Theranostic Nanomedicine Fluorescence spectroscopy Inorganic Chemistry Metal Europium Coordination Complexes Polysaccharides [CHIM.COOR]Chemical Sciences/Coordination chemistry Fluorescent Dyes Viscosity 010405 organic chemistry Fluorescence Polyelectrolyte 0104 chemical sciences Spectrometry Fluorescence chemistry visual_art Drug delivery visual_art.visual_art_medium Alteromonas Luminescence |
| Zdroj: | Dalton Transactions Dalton Transactions, Royal Society of Chemistry, 2021, 50 (46), pp.17215-17227. ⟨10.1039/D1DT03288G⟩ Dalton Transactions, 2021, 50 (46), pp.17215-17227. ⟨10.1039/D1DT03288G⟩ |
| ISSN: | 1477-9234 1477-9226 |
| DOI: | 10.1039/d1dt03288g |
| Popis: | International audience; Exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium, showed anti-metastatic properties in osteosarcoma (bone tumor). These EPSs could be employed as new drug deliverysystems for therapeutic uses. They may represent a new class of ligands to be combined in a theranosticapproach with fluorescent metals, such as Eu(III), to serve as imaging probe. The goal of this work was toinvestigate the feasibility of such coupling by time-resolved laser-induced fluorescence spectroscopy(TRLFS). Since these EPSs are polyelectrolytes their conformation could affect the complexation properties.Thus, viscosimetric measurements were performed as a function of their concentration as well asthe background electrolyte concentration. Polysaccharides conformation exhibited a lower hydrodynamicvolume for the highest ionic strengths. The resulting random-coiled conformation could affect the complexationwith metal for high concentration but no change was evidenced when increasing europiumconcentration. Two sites of complexation of Eu(III) were evidenced by TRLFS in heparin, whereas only onesite was evidenced in two modified EPSs produced from Alteromonas infernus. |
| Databáze: | OpenAIRE |
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