Huaier Augmented the Chemotherapeutic Sensitivity of Oxaliplatin via Downregulation of YAP in Hepatocellular Carcinoma
| Autor: | Bin Liang, Zijun Qian, Yongchun Yu, Rui Chen, Feng Cai, Liang Shan, Hongyuan Jiang, Haiyin Zheng, Yuquan Tao, Lifang Ma, Zongguo Yang, Xin Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Hepatocellular carcinoma
medicine.medical_treatment chemotherapeutic sensitivity 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation synergistic effect medicine polycyclic compounds Huaier Chemotherapy Chemistry oxaliplatin biochemical phenomena metabolism and nutrition medicine.disease digestive system diseases Blockade Oxaliplatin Oncology Apoptosis Cell culture 030220 oncology & carcinogenesis CYR61 Cancer research 030211 gastroenterology & hepatology YAP medicine.drug Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | For unresectable Hepatocellular carcinoma (HCC), chemotherapy is still an important treatment strategy. Oxaliplatin (Oxa) is an effective treatment of HCC after sorafenib treatment failure. However, the intrinsic or acquired resistance of Oxa affected the chemotherapeutic sensitivity. By analyzing the data of GEO Database, we found that Oxa aberrantly increased the expression of Cysteine-rich61 (Cyr61) in HCC cell lines. Subsequently, in Bel-7404 and SMMC-7721 cells after treated with Oxa, it was verified that the expression of Cyr61 and Yes-associated protein (YAP) was increased. Moreover, we found that blockade of YAP promoted Oxa-induced cell apoptosis for the first time. Meanwhile, our previous study demonstrated that Huaier (HE) inhibited the expression of YAP. Further study found that combination treatment of Oxa and HE had a significantly synergistic anti-cancer effect and significantly inhibited the expression of YAP and apoptosis related proteins. Taken together, we have observed that overexpression of YAP significantly reduced the chemotherapeutic sensitivity of Oxa in HCC for the first time. Combination treatment of Oxa and HE solved this problem. |
| Databáze: | OpenAIRE |
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