Effects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by MEG: study protocol for a randomized controlled trial

Autor: Keh-chung Lin, Chia-Hsiung Cheng, Chih Chi Chen, Chia-Ling Chen, Chih jou Lai, Tsai yu Shih, Yu-wei Hsieh, Ching-yi Wu
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
030506 rehabilitation
Time Factors
medicine.medical_treatment
Video Recording
Medicine (miscellaneous)
Functional Laterality
Mirror therapy
law.invention
Study Protocol
Disability Evaluation
0302 clinical medicine
Randomized controlled trial
Clinical Protocols
law
Modified Rankin Scale
Feedback
Sensory
Telerehabilitation
Surveys and Questionnaires
Pharmacology (medical)
Stroke
Aged
80 and over
lcsh:R5-920
Rehabilitation
Motor Cortex
Stroke Rehabilitation
Action observation
Magnetoencephalography
Middle Aged
Functional Independence Measure
Treatment Outcome
Research Design
Visual Perception
Female
0305 other medical science
Motor learning
lcsh:Medicine (General)
Adult
medicine.medical_specialty
Taiwan
Motor Activity
Upper Extremity
03 medical and health sciences
Young Adult
Physical medicine and rehabilitation
Predictive Value of Tests
medicine
Humans
Neurorehabilitation
Aged
Afferent Pathways
business.industry
Recovery of Function
medicine.disease
Imitative Behavior
Physical therapy
business
030217 neurology & neurosurgery
Zdroj: Trials, Vol 18, Iss 1, Pp 1-8 (2017)
Trials
ISSN: 1745-6215
DOI: 10.1186/s13063-017-2205-z
Popis: Background Loss of upper-extremity motor function is one of the most debilitating deficits following stroke. Two promising treatment approaches, action observation therapy (AOT) and mirror therapy (MT), aim to enhance motor learning and promote neural reorganization in patients through different afferent inputs and patterns of visual feedback. Both approaches involve different patterns of motor observation, imitation, and execution but share some similar neural bases of the mirror neuron system. AOT and MT used in stroke rehabilitation may confer differential benefits and neural activities that remain to be determined. This clinical trial aims to investigate and compare treatment effects and neural activity changes of AOT and MT with those of the control intervention in patients with subacute stroke. Methods/design An estimated total of 90 patients with subacute stroke will be recruited for this study. All participants will be randomly assigned to receive AOT, MT, or control intervention for a 3-week training period (15 sessions). Outcome measurements will be taken at baseline, immediately after treatment, and at the 3-month follow-up. For the magnetoencephalography (MEG) study, we anticipate that we will recruit 12 to 15 patients per group. The primary outcome will be the Fugl-Meyer Assessment score. Secondary outcomes will include the modified Rankin Scale, the Box and Block Test, the ABILHAND questionnaire, the Questionnaire Upon Mental Imagery, the Functional Independence Measure, activity monitors, the Stroke Impact Scale version 3.0, and MEG signals. Discussion This clinical trial will provide scientific evidence of treatment effects on motor, functional outcomes, and neural activity mechanisms after AOT and MT in patients with subacute stroke. Further application and use of AOT and MT may include telerehabilitation or home-based rehabilitation through web-based or video teaching. Trial registration ClinicalTrials.gov, ID: NCT02871700. Registered on 1 August 2016. Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-2205-z) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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