Budding Yeast Has a Minimal Endomembrane System
| Autor: | Kasey J. Day, Jason C. Casler, Benjamin S. Glick |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Endosome media_common.quotation_subject Endocytic cycle Golgi Apparatus macromolecular substances Endosomes Biology environment and public health General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences symbols.namesake Endomembrane system Internalization Molecular Biology media_common Chemistry Early endosome Cell Membrane Biological Transport Cell Biology Golgi apparatus Budding yeast Yeast Endocytosis Cell biology Recycling endosome 030104 developmental biology Saccharomycetales symbols Developmental Biology trans-Golgi Network |
| Zdroj: | Developmental cell. 44(1) |
| ISSN: | 1878-1551 |
| Popis: | Summary The endomembrane system consists of the secretory and endocytic pathways, which communicate by transport to and from the trans- Golgi network (TGN). In mammalian cells, the endocytic pathway includes early, late, and recycling endosomes. In budding yeast, different types of endosomes have been described, but the organization of the endocytic pathway has remained unclear. We performed a spatial and temporal analysis of yeast endosomal markers and endocytic cargoes. Our results indicate that the yeast TGN also serves as an early and recycling endosome. In addition, as previously described, yeast contains a late or prevacuolar endosome (PVE). Endocytic cargoes localize to the TGN shortly after internalization, and manipulations that perturb export from the TGN can slow the passage of endocytic cargoes to the PVE. Yeast apparently lacks a distinct early endosome. Thus, yeast has a simple endocytic pathway that may reflect the ancestral organization of the endomembrane system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|