Percutaneous penetration of silver from a silver containing garment in healthy volunteers and patients with atopic dermatitis
| Autor: | Olivier A. Pluut, Carlotta Bianco, Francesca Larese-Filon, Sanja Kezic, Maaike J. Visser, Ivone Jakasa, Petra Krystek, Thomas Rustemeyer |
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| Přispěvatelé: | Dermatology, CCA - Innovative therapy, Other departments, APH - Amsterdam Public Health, Coronel Institute of Occupational Health, Pluut, Oa, Bianco, Carlotta, Jakasa, I, Visser, Mj, Krystek, P, LARESE FILON, Francesca, Rustemeyer, T, Kezic, S. |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Silver Skin Absorption Urine Percutaneous penetration Toxicology Risk Assessment Dermal exposure Clothing Dermatitis Atopic Interleukin-1alpha Healthy volunteers medicine Stratum corneum Humans Atopic dermatitis Cytokines Cytokine Netherlands Skin integumentary system business.industry Textiles Healthy subjects General Medicine Atopic dermatiti medicine.disease Dermatology Healthy Volunteers Interleukin 1 Receptor Antagonist Protein medicine.anatomical_structure Healthy individuals Body Burden Female Inflammation Mediators business |
| Zdroj: | Toxicology Letters, 235(2), 116-122. Elsevier BV Toxicology letters, 235(2), 116-122. Elsevier BV Pluut, O A, Bianco, C, Jakasa, I, Visser, M J, Krystek, P, Larese-Filon, F, Rustemeyer, T & Kezic, S 2015, ' Percutaneous penetration of silver from a silver containing garment in healthy volunteers and patients with atopic dermatitis ', Toxicology Letters, vol. 235, no. 2, pp. 116-122 . https://doi.org/10.1016/j.toxlet.2015.03.014 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/j.toxlet.2015.03.014 |
| Popis: | Human data on dermal absorption of silver under “in use” scenario are scarce which hampers health risk assessment. The main objective of the present study was to determine percutaneous penetration of silver after dermal exposure to silver containing garment in healthy individuals and atopic dermatitis (AD) patients. Next to assess pro-inflammatory effect of silver in the skin. Healthy subjects (n = 15) and patients with AD (n = 15) wore a sleeve containing 3.6% (w/w) silver on their lower arms for 8 h during 5 consecutive days. The percutaneous penetration parameters were deduced from the silver concentration-depth profiles in the stratum corneum (SC) collected by adhesive tapes. Furthermore, silver was measured in urine samples collected before and after exposure. Inflammatory response was assessed by measuring IL-1a and IL- 1RA in the exposed and non-exposed skin sites. Dermal flux of silver in healthy subjects and AD patients was respectively 0.23 and 0.20 ng/cm2/h. The urine silver concentrations showed no increase after exposure. Furthermore, exposure to silver did not lead to the changes in the profiles of IL-1a and IL-1RA. Dermal absorption of silver under “real life scenario” was lower than the current reference dose. Furthermore, dermal exposure did not lead to altered expression of inflammatory IL-1 cytokines in the skin. |
| Databáze: | OpenAIRE |
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