Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic Or Conventional Cholecystectomy
| Autor: | Tamara Alempijevic, Vasilije Jeremić, Sanja Jovanović, B. Stefanovic, Srdjan Mijatovic, Slobodan Krstic, Branislav Stefanovic, Nikola Radmanović |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment laparoscopy aparoscopy cholecystectomy medicine.disease_cause Nitric oxide lcsh:Biochemistry 03 medical and health sciences chemistry.chemical_compound stress 0302 clinical medicine Emergency surgery nitric oxide medicine In patient lcsh:QD415-436 Prospective cohort study Laparoscopic cholecystectomy Original Paper nitrotyrosine business.industry Nitrotyrosine General surgery 3. Good health Surgery chemistry 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Cholecystectomy business Oxidative stress |
| Zdroj: | Journal of Medical Biochemistry Journal of Medical Biochemistry, Vol 36, Iss 2, Pp 171-176 (2017) |
| ISSN: | 1452-8258 |
| Popis: | Oxidative stress represents tissue damage caused by reactive forms of oxygen and nitrogen due to the inability of antioxidant mechanisms to reduce reactive forms into more stable ones. The aim of the study was to evaluate the influence of surgical trauma on nitric oxide (NO) and nitrotyrosine (NT) values in patients undergoing conventional and laparoscopic cholecystectomy.A prospective study included sixty patients from the Department of Emergency Surgery, Clinical Centre of Serbia who were operated for gallstone related chronic cholecystitis. All the patients enrolled in the study underwent cholecystectomy; the first group was operated conventionally (30 patients - control group), while the second group was operated laparoscopically (30 patients - treatment group).There were no statistically significant differences in the values of NO and its postoperative changes in both groups, the conventionally operated group (p=0.943) and the laparoscopically operated group (p=0.393). We found an increase in NT values 24 hours postoperatively (p=0.000) in the conventionally operated patients, while in the group operated laparoscopically we didn't find statistically significant changes in the values of NT (conventionally operated group (p=0.943) and laparoscopically operated group (p=0.393)).In our study, we found a significant increase in NT values 24 hours postoperatively in conventionally operated patients i.e. the control group, vs. the treatment group. Further randomized studies are needed for a better understanding of the impact of surgical trauma on oxidative stress response.Oksidativni stres predstavlja oštećenje tkiva izazvano reaktivnim oblicima kiseonika i azota usled nesposobnosti antioksidantnih mehanizama da redukuju reaktivne oblike u stabilnije forme. Cilj ove studije bio je da se proceni uticaj hirurške traume na vrednosti azot-monoksida (NO) i nitrotirozina (NT) kod pacijenata podvrgnutih konvencionalnoj i laparoskopskoj holecistektomiji.Ova prospektivna studija obuhvatila je 60 pacijenata sa Klinike za urgentnu hirurgiju Kliničkog centra Srbije koji su operisani zbog hroničnog holecistitisa vezanog za kamen u žučnoj kesi. Svi pacijenti uključeni u studiju podvrgnuti su holecistektomiji, prva grupa konvencionalnoj (30 pacijenata – kontrolnagrupa), dok jedruga grupa operisana laparoskopski (30 pacijenata – terapijska grupa).Nije bilo statistički značajnih razlika između vrednosti NO ili postoperativnih promena ovih vrednosti u obe grupe, konvencionalno operisanoj grupi (p=0,943) i laparoskopski operisanoj grupi (p=0,393). Otkrili smo porast vrednosti NT 24 časa posle operacije (p=0,000) kod konvencionalno operisanih pacijenata, dok u grupi operisanoj laparoskopski nismo pronašli statistički značajne promene vrednosti NT(konvencionalno operisana grupa: p=0,943 i laparoskopski operisana grupa: p=0,393).U ovoj studiji, značajan porast vrednosti NT 24 časa posle operacije utvrđen je u kontrolnoj grupi konvencionalno operisanih pacijenata u odnosu na terapijsku grupu. Potrebne su dalje nasumične kontrolisane studije kako bi se bolje razumeo uticaj hirurške traume na odgovor na oksidativni stres. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|