Valsartan/amlodipine compared to nifedipine GITS in patients with hypertension inadequately controlled by monotherapy
| Autor: | Ji-Guang, Wang, Wei-Fang, Zeng, Yu-Song, He, Liang-Long, Chen, Meng, Wei, Zhao-Ping, Li, Bao-Wei, Zhang, Yan, Li, Chuanyu, Gao |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Nifedipine medicine.drug_class Tetrazoles Calcium channel blocker Pharmacology law.invention Randomized controlled trial Asian People law Internal medicine medicine Humans Pharmacology (medical) In patient Amlodipine Antihypertensive Agents business.industry General Medicine Middle Aged Amlodipine Valsartan Drug Combination Nifedipine gits Drug Combinations Blood pressure Treatment Outcome Valsartan Delayed-Action Preparations Hypertension Cardiology Female business medicine.drug |
| Zdroj: | Advances in therapy. 30(8) |
| ISSN: | 1865-8652 |
| Popis: | Current hypertension guidelines recommend single-pill combinations because they not only improve convenience and compliance to therapy and thus blood pressure (BP) control, but also reduce health-care costs. This study compared the efficacy and safety of valsartan/amlodipine single-pill combination with nifedipine gastrointestinal therapeutic system (GITS) in Chinese patients with hypertension who were inadequately controlled with monotherapy.In this multicenter, open-label, active-controlled, parallel-group study, 564 patients with hypertension not adequately controlled by prior monotherapy were randomized to receive valsartan/amlodipine 80/5 mg or nifedipine GITS 30 mg once daily for 12 weeks.In the intention-to-treat analysis (n = 540), valsartan/amlodipine (n = 272) showed a least-square mean reduction of -16.6 versus -10.8 mmHg by nifedipine GITS (n = 268; mean between-treatment difference: -5.8 mmHg; P 0.0001) from baseline to week 12. The corresponding results for mean sitting diastolic BP were -8.6 and -4.6 mmHg, respectively (difference: -4.0 mmHg; P 0.0001). The percentage of patients achieving the BP target (140/90 or130/80 mmHg in the absence or presence of diabetes mellitus, respectively) was significantly higher with valsartan/amlodipine (79.0%) versus nifedipine GITS (57.4%; P 0.0001). The overall incidence rate of adverse events was lower with valsartan/amlodipine (19.2%) than with nifedipine GITS (29.4%; P = 0.004).The valsartan/amlodipine 80/5 mg single-pill combination is well tolerated and more effective than nifedipine GITS 30 mg for BP control in Chinese patients with hypertension. |
| Databáze: | OpenAIRE |
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