Effect of antimycotic agents on the activity of aspartyl proteinases secreted by Candida albicans
| Autor: | Bernhard Hube, Gerald Hamm, Nikola Krnjaic, Hans C. Korting, Martin Schaller, M. Niewerth |
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| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Antifungal Agents Microbiology Amprenavir chemistry.chemical_compound Amphotericin B Candida albicans medicine Cell Adhesion Aspartic Acid Endopeptidases Protease inhibitor (pharmacology) Furans Saquinavir Sulfonamides biology Dose-Response Relationship Drug General Medicine HIV Protease Inhibitors biology.organism_classification Corpus albicans chemistry Terbinafine Ketoconazole Carbamates Pepstatin medicine.drug |
| Zdroj: | Journal of medical microbiology. 52(Pt 3) |
| ISSN: | 0022-2615 |
| Popis: | The inhibitory effect of human immunodeficiency virus (HIV) proteinase inhibitors amprenavir and saquinavir and antifungal agents terbinafine, ketoconazole, amphotericin B and ciclopiroxolamine on aspartyl proteinases (Saps) secreted by Candida albicans was tested in an in vitro spectophotometric assay. As expected, both HIV proteinase inhibitors showed a significant inhibitory effect on Sap activity, which was comparable to that of the classical aspartyl proteinase inhibitor pepstatin A (P < 0.001). Antifungal drugs such as ketoconazole, terbinafine and amphotericin B had no, or only minor, inhibitory effects on proteolytic activity. In contrast, a significant reduction in Sap activity could be demonstrated during treatment with the antifungal agent ciclopiroxolamine (P < 0.001). These results point to a multiple effect of this antimycotic agent and might explain the reduced adherence of C. albicans to human epithelial cells at subinhibitory doses. |
| Databáze: | OpenAIRE |
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