Transurethral intraprostatic Botulinum toxin-A injection: a novel treatment for BPH refractory to current medical therapy in poor surgical candidates
| Autor: | Gholamreza Mokhtari, Abtin Heidarzadeh, Samaneh Esmaeili, Alireza Farzan, Mani Mohiti Asli, Ahmad Enshaei, Ali Madani |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Urology Prostatic Hyperplasia Pilot Projects urologic and male genital diseases Injections Lower Urinary Tract Symptoms Refractory Quality of life Lower urinary tract symptoms Prostate Internal medicine medicine Humans Nocturia Botulinum Toxins Type A Aged business.industry Organ Size Middle Aged Hyperplasia medicine.disease Surgery Clinical trial Treatment Outcome medicine.anatomical_structure Neuromuscular Agents Quality of Life medicine.symptom business |
| Zdroj: | World Journal of Urology. 31:235-239 |
| ISSN: | 1433-8726 0724-4983 |
| DOI: | 10.1007/s00345-012-0851-z |
| Popis: | Benign prostatic hyperplasia (BPH) is the main cause of lower urinary tract symptoms (LUTS) in elderly men. Some patients respond poorly to routine medical therapy and are not well suited for surgery, too. This study was planned to evaluate the effect of Botulinum-A on BPH refractory to current medical therapy in poor surgical candidates. In this clinical trial, 10 patients with LUTS suggestive of BPH who had responded poorly to medical therapy for at least 6 months and were poor surgical candidates, were received different doses of transurethral Botulinum-A injection based on their prostate volume. The prostate volume, PSA, Qmax, IPSS, PVR and frequency of nocturia were evaluated and compared before and after treatment. The mean IPSS was 24.50 ± 3.8 and 13.40 ± 2.67 before and after the treatment, respectively (P |
| Databáze: | OpenAIRE |
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