The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential
Autor: | Laurent Martiny, Sébastien Blaise, Béatrice Romier-Crouzet, Ludivine Odoul, Amandine Scandolera, Laurent Debelle, Laurent Duca, Pascal Maurice, Alexandre Guillot, Hassan El Btaouri, Stéphanie Salesse, Charlotte Kawecki |
---|---|
Přispěvatelé: | Givaudan ACI, Soliance, Institute of Pathology, University of Bern, Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire de Signalisation et Récepteurs Matriciels (SiRMa), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Pennington Biomedical Center |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Angiogenesis Mini Review extracellular matrix [SDV]Life Sciences [q-bio] Integrin Biology therapeutic targets Extracellular matrix 03 medical and health sciences 0302 clinical medicine elastokines Pharmacology (medical) [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Receptor ComputingMilieux_MISCELLANEOUS Pharmacology Tropoelastin Binding protein lcsh:RM1-950 ERC 3. Good health Cell biology lcsh:Therapeutics. Pharmacology 030104 developmental biology Biochemistry 030220 oncology & carcinogenesis biology.protein Signal transduction neuraminidase-1 Elastin |
Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Frontiers, 2016, 7, ⟨10.3389/fphar.2016.00032⟩ Frontiers in Pharmacology, Vol 7 (2016) |
ISSN: | 1663-9812 |
DOI: | 10.3389/fphar.2016.00032⟩ |
Popis: | Elastin, one of the longest-lived proteins, confers elasticity to tissues with high mechanical constraints. During aging or pathophysiological conditions such as cancer progression, this insoluble polymer of tropoelastin undergoes an important degradation leading to the release of bioactive elastin-derived peptides (EDPs), named elastokines. EDP exhibit several biological functions able to drive tumor development by regulating cell proliferation, invasion, survival, angiogenesis, and matrix metalloproteinase expression in various tumor and stromal cells. Although, several receptors have been suggested to bind elastokines (αvβ3 and αvβ5 integrins, galectin-3), their main receptor remains the elastin receptor complex (ERC). This heterotrimer comprises a peripheral subunit, named elastin binding protein (EBP), associated to the protective protein/cathepsin A (PPCA). The latter is bound to a membrane-associated protein called Neuraminidase-1 (Neu-1). The pro-tumoral effects of elastokines have been linked to their binding onto EBP. Additionally, Neu-1 sialidase activity is essential for their signal transduction. Consistently, EDP-EBP interaction and Neu-1 activity emerge as original anti-tumoral targets. Interestingly, besides its direct involvement in cancer progression, the ERC also regulates diabetes outcome and thrombosis, an important risk factor for cancer development and a vascular process highly increased in patients suffering from cancer. In this review, we will describe ERC and elastokines involvement in cancer development suggesting that this unique receptor would be a promising therapeutic target. We will also discuss the pharmacological concepts aiming at blocking its pro-tumoral activities. Finally, its emerging role in cancer-associated complications and pathologies such as diabetes and thrombotic events will be also considered. |
Databáze: | OpenAIRE |
Externí odkaz: |