Rapid course radiation therapy vs. more standard treatment: A randomized trial for bone metastases
| Autor: | Ulrich Abel, Heinz-Joachim Tkocz, Carsten Nieder, K. Walter, W Berberich, Reinhard Kubale, Thomas Scheib, Marcus Fuchs, Marcus Niewald, Klaus Schnabel |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Bone disease medicine.medical_treatment Bone Neoplasms Metastasis law.invention Randomized controlled trial law medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Aged Aged 80 and over Radiation business.industry Standard treatment Middle Aged Prognosis medicine.disease Primary tumor Surgery Radiation therapy Clinical trial Oncology Female business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 36:1085-1089 |
| ISSN: | 0360-3016 |
| Popis: | In a prospective randomized trial we examined whether radiotherapy of painful bone metastases can be shortened using larger single doses without impairing effectivity.One hundred patients with painful bone metastases having no prior surgical intervention or treatment with x-ray therapy and had a median follow-up of 12 months were analyzed. The primary tumor was located in the breast in 43%, in the lung in 24%, and in the prostate in 14%. The most frequent sites of metastases were the pelvis (31%), the vertebral column (30%), and the ribs (20%). Further percentages of sites were: lower extremity 11%, upper extremity 6%, and skull 2%. Fifty-one patients received a short course radiotherapy with a total dose of 20 Gy in 1 week (daily dose 4 Gy), and 49 patients received 30 Gy in 3 weeks (daily dose 2 Gy).There were no significant differences in frequency, duration of pain relief, improvement of mobility, recalcification, frequency of pathologic fractures nor survival. There was a light trend favoring 30 Gy in frequency of pain relief and recalcification. Survival was mostly influenced by primary tumor site, Karnofsky performance status, and possibly by the response to radiotherapy (pain relief).Because of the very short life expectancy of patients with metastatic bone disease, we now use 20 Gy in 1 week as our standard to reduce hospital stay. |
| Databáze: | OpenAIRE |
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