Renal dysfunctions in glomerulonephropathy with rapidly declined renal failure
| Autor: | Dhevy Watana, Sitprija, Futrakul P, Narisa Futrakul, Makumkrong Poshyachinda, Rajanee Sensirivatana, Singkhwa, Pochanugool C, Yenrudi S |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
medicine.medical_specialty Renal Plasma Flow Adolescent Nephrosis Kidney Glomerulus Urology Renal function urologic and male genital diseases Critical Care and Intensive Care Medicine Renal Circulation Internal medicine Medicine Humans Renal Insufficiency Child Renal circulation business.industry Capillary Resistance General Medicine Blood flow Effective renal plasma flow medicine.disease Filtration fraction Perfusion medicine.anatomical_structure Endocrinology Kidney Tubules Nephrology Renal blood flow Child Preschool business Tubulointerstitial Disease |
| Zdroj: | Renal failure. 18(4) |
| ISSN: | 0886-022X |
| Popis: | Eight patients aged between 5 and 26 years developed rapid deterioration of renal function and became oliguric/anuric with duration ranging from 1 to 21 days. The initial functional assessment revealed severe degree of glomerular, tubular, and vascular dysfunctions. The magnitude of renal dysfunction was quantified and expressed in terms of a clinical score. The degree of glomerular and tubular dysfunctions were inversely proportional to the renal plasma flow and peritubular capillary blood flow (PTCB), respectively. Similar findings have been observed in a variety of severe glomerulonephropathies. In this aspect, it is likely that the reduction of peritubular capillary blood flow and tubulointerstitial disease are interrelated. Further evidence to support the primary role of reduction of PTCB in inducing tubulointerstitial disease is provided by the following: (a) Reduction of PTCB is documented in mesangial proliferative nephrosis with steroid resistance prior to the detection of tubulointerstitial disease. (b) Ischemic insult can induce tubulointerstitial disease in experimental setting of renal artery occlusion in animal, (c) Improved tubular function can be achieved following the increase in PTCB with the enhanced renal perfusion therapy. |
| Databáze: | OpenAIRE |
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