The positivity rate of 68Gallium-PSMA-11 ligand PET/CT depends on the serum PSA-value in patients with biochemical recurrence of prostate cancer
| Autor: | Mathias Schreckenberger, Helmut J. Wieler, Ludwin Trampert, Hans-Georg Buchholz, Manuela A Hoffmann, Jonas Müller-Hübenthal, Thomas Höfner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Biochemical recurrence medicine.medical_specialty Urology 68Gallium-PSMA PET/CT urologic and male genital diseases 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine biochemical recurrence Doubling time prostate-specific antigen PET-CT PSA Velocity business.industry positivity rate medicine.disease prostate cancer Prostate-specific antigen 030104 developmental biology Oncology 030220 oncology & carcinogenesis Localized disease Recurrent Prostate Carcinoma business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Background: The aim of the present study is to analyze the efficacy of 68Gallium (Ga)-PSMA-11 PET/CT for detecting and localizing recurrent prostate carcinoma (PC) in patients with different prostate-specific antigen (PSA), PSA velocity (PSAvel) and doubling time (PSAdt). Results: The PR of 68Ga-PSMA-11 PET/CT showed a positive relationship with PSA levels. Even at restaging PSA-values (PSAV) of lower than 0.2 ng/ml, PR was 41%. For PSAV of 0.2-5 ng/ml/y. No significant association was found for PSAdt. Methods: PET/CT scans of 660 patients with biochemical recurrence (BCR) after primary therapy of PC were included in the analysis. We correlated serum PSA levels, measured at the time of imaging with PSMA PET/CT-positivity rates (PR) as well as PSAvel (in 225 patients) and PSAdt (660 patients). Additionally we compared the incidence of localized disease to metastases as related to these PSA-biomarkers. Conclusion: We have shown, in a large cohort of patients, that 68Ga-PSMA-11 PET/CT is a sensitive tool for restaging PC and has a high detection efficacy, even in patients with very low PSA levels ( |
| Databáze: | OpenAIRE |
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