Co-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3

Autor: Syrjänen, K., Shabalova, I., Naud, P., Derchain, S., Sarian, L., Kozachenko, V., Zakharchenko, S., Roteli-Martins, C., Nerovjna, R., Longatto, Adhemar, Kljukina, L., Tatti, S., Branovskaja, M., Branca, M., Grunjberga, V., Erzen, M., Juschenko, A., Hammes, L. Serpa, Costa, S., Podistov, J., Syrjänen, S., NIS, LAMS Study Research Groups
Přispěvatelé: Universidade do Minho
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Oncology
Sexually transmitted disease
Multivariate analysis
Medicina Básica [Ciências Médicas]
NIS Cohort
Risk Factors
Pharmacology (medical)
Papillomaviridae
CIN
Prospective cohort study
Aged
80 and over
biology
Progression
Multinomial regression
Incidence
Confounding
Middle Aged
female genital diseases and pregnancy complications
Infectious Diseases
medicine.anatomical_structure
Cohort
Ciências Médicas::Medicina Básica
Female
Adult
medicine.medical_specialty
HPV
LAMS Study
Adolescent
Prospective follow-up
Dermatology
Cervical intraepithelial neoplasia
Young Adult
Internal medicine
medicine
Humans
Cervical Intraepithelial Neoplasia
Cervix
Aged
Gynecology
Science & Technology
business.industry
Papillomavirus Infections
Public Health
Environmental and Occupational Health
Uterine Cervical Dysplasia
biology.organism_classification
medicine.disease
Co-factors
Latin America
business
USSR
Zdroj: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Popis: In addition to oncogenic 'high-risk' human papillomaviruses (HR-HPV), several co-factors are needed in cervical carcinogenesis, but it is poorly understood whether these HPV co-factors associated with incident cervical intraepithelial neoplasia (CIN) grade 1 are different from those required for progression to CIN2 and CIN3. To gain further insights into the true biological differences between CIN1, CIN2 and CIN3, we assessed HPV co-factors increasing the risk of incident CIN1, CIN2 and CIN3. Data from the New Independent States of the Former Soviet Union (NIS) Cohort (n = 3187) and the Latin American Screening (LAMS) Study (n = 12,114) were combined, and co-factors associated with progression to CIN1, CIN2 and CIN3 were analysed using multinomial logistic regression models with all covariates recorded at baseline. HR-HPV-positive women (n = 1105) represented a subcohort of all 1865 women prospectively followed up in both studies. Altogether, 90 (4.8%), 39 (2.1%) and 14 (1.4%) cases progressed to CIN1, CIN2 and CIN3, respectively. Baseline HR-HPV was the single most powerful predictor of incident CIN1, CIN2 and CIN3. When controlled for residual HPV confounding by analysing HR-HPV-positive women only, the risk profiles of incident CIN1, CIN2 and CIN3 were unique. Completely different HPV co-factors were associated with progression to CIN1, CIN2 and CIN3 in univariate and multivariate analyses, irrespective of whether non-progression, CIN1 or CIN2 was used as the reference outcome. HPV co-factors associated with progression to CIN1, CIN2 and CIN3 display unique profiles, implicating genuine biological differences between the three CIN grades, which prompts us to re-visit the concept of combining CIN2 with CIN3 or CIN1.
NIS Cohort study was supported by the INCO-Copernicus Program of the European Commission (Contract No. ERB IC15-CT98-0321), and the LAMS study by the European Commission, INCO-DEV Programme (Contract# ICA4-CT-2001-10013). Special thanks are due to Digene Corp. for providing the Hybrid Capture analyser, samplers and the test kits at our disposal
Databáze: OpenAIRE
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