Assessment of single-vessel cerebral blood velocity by phase contrast fMRI

Autor: Yuanyuan Jiang, Xuming Chen, Klaus Scheffler, S Choi, Rolf Pohmann, David Kleinfeld, Xin Yu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
genetic structures
Physiology
Hemodynamics
Cardiovascular Analysis
Diagnostic Radiology
Rats
Sprague-Dawley
Venules
Functional Magnetic Resonance Imaging
Blood Flow
Medicine and Health Sciences
Contrast (vision)
Biology (General)
media_common
Cerebral Blood Flow Assay
Brain Mapping
medicine.diagnostic_test
General Neuroscience
Radiology and Imaging
Methods and Resources
Brain
Hematology
Magnetic Resonance Imaging
Body Fluids
Arterioles
Blood
Bioassays and Physiological Analysis
Cerebrovascular Circulation
Anatomy
General Agricultural and Biological Sciences
Blood Flow Velocity
psychological phenomena and processes
QH301-705.5
Imaging Techniques
media_common.quotation_subject
Posterior parietal cortex
Neuroimaging
Biology
Research and Analysis Methods
behavioral disciplines and activities
General Biochemistry
Genetics and Molecular Biology
Arteriole
Diagnostic Medicine
medicine.artery
medicine
Animals
Vascular dementia
General Immunology and Microbiology
Biology and Life Sciences
Magnetic resonance imaging
Blood flow
medicine.disease
Oxygen
nervous system
Cardiovascular Anatomy
Blood Vessels
Functional magnetic resonance imaging
Biomedical engineering
Neuroscience
Zdroj: PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3000923 (2021)
ISSN: 1545-7885
1544-9173
Popis: Current approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level–dependent (BOLD) fMRI, while the second is through changes in arteriole diameter, i.e., cerebral blood volume (CBV) fMRI. Here, we introduce cerebral blood flow–related velocity-based fMRI, denoted CBFv-fMRI, which uses high-resolution phase contrast (PC) MRI to form velocity measurements of flow. We use CBFv-fMRI in measure changes in blood velocity in single penetrating microvessels across rat parietal cortex. In contrast to the venule-dominated BOLD and arteriole-dominated CBV fMRI signals, CBFv-fMRI is comparable from both arterioles and venules. A single fMRI platform is used to map changes in blood pO2 (BOLD), volume (CBV), and velocity (CBFv). This combined high-resolution single-vessel fMRI mapping scheme enables vessel-specific hemodynamic mapping in animal models of normal and diseased states and further has translational potential to map vascular dementia in diseased or injured human brains with ultra–high-field fMRI.
This study presents a phase contrast-based, high field MRI-based approach for the functional mapping of cerebral blood velocity in individual cortical arterioles and venules in the rat cortex; this approach can be combined with previously established approaches to map BOLD, CBV, and blood velocity from penetrating microvessels.
Databáze: OpenAIRE
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