Serum binding of nifedipine and verapamil in patients with ischaemic heart disease on monotherapy
| Autor: | DO Rumiantsev, S. Martsevich Yu, Kokurina Ev, Metelitsa Vi, Slastnikova Id, VK Piotrovskii |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Nifedipine medicine.medical_treatment Metabolite Ischemia Coronary Disease chemistry.chemical_compound In vivo Oral administration Internal medicine medicine Humans Pharmacology (medical) Pharmacology Chemotherapy business.industry Blood Proteins Middle Aged medicine.disease Blood proteins Endocrinology Verapamil chemistry business Dialysis Protein Binding Research Article medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 28:357-361 |
| ISSN: | 0306-5251 |
| Popis: | Serum free fractions of nifedipine, verapamil and some of their metabolites were measured in patients with ischaemic heart disease receiving single oral dose and chronic monotherapy and were compared with those obtained in vitro. The percentages of unbound nifedipine and verapamil in vitro (concentration range 50-200 and 150-400 ng ml-1, respectively) were 2.51 and 7.23%, respectively, and did not differ from those found on monotherapy with these drugs (2.05 and 8.08%, respectively), and after single dosing. It is suggested that, during treatment with nifedipine or verapamil, their serum metabolites do not affect binding of the parent drugs to serum proteins. |
| Databáze: | OpenAIRE |
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