Thalidomide for steroid-dependent chronic disseminated candidiasis after stem cell transplantation: A case report

Autor: Thorsten Braun, Grégory Jouvion, Olivier Lortholary, Jean-Michel Correas, Sophie Candon, C. Maunoury, Blandine Rammaert, Marie-Elisabeth Bougnoux
Přispěvatelé: Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie biologique [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Université Sorbonne Paris Cité (USPC), Médecine nucléaire [CHU HEGP], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Histopathologie humaine et Modèles animaux, Institut Pasteur [Paris], Service d'hématologie clinique [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Service de Radiologie Adultes, Centre National de Référence des Mycoses invasives et antifongiques - Mycologie moléculaire (CNRMA), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Antifungal Agents
MESH: Thalidomide/administration & dosage
chronic disseminated candidiasis
[SDV]Life Sciences [q-bio]
MESH: Candidiasis/immunology
MESH: Transplantation
Homologous/adverse effects
MESH: Candidiasis/diagnostic imaging
MESH: Glucocorticoids/therapeutic use
MESH: Magnetic Resonance Imaging
Recurrence
Positron Emission Tomography Computed Tomography
Candida albicans
MESH: Neutropenia/complications
Fluconazole
MESH: Candidiasis/drug therapy
health care economics and organizations
Bone Marrow Transplantation
Candida
MESH: Treatment Outcome
MESH: Middle Aged
Candidiasis
Middle Aged
Hodgkin Disease
Magnetic Resonance Imaging
MESH: Bone Marrow Transplantation/adverse effects
Thalidomide
MESH: Glucocorticoids/administration & dosage
MESH: Glucocorticoids/adverse effects
3. Good health
Treatment Outcome
MESH: Immunosuppressive Agents/therapeutic use
Infectious Diseases
[SDV.IMM]Life Sciences [q-bio]/Immunology
Stem cell
MESH: Antifungal Agents/administration & dosage
Immunosuppressive Agents
MESH: Immunosuppressive Agents/administration & dosage
medicine.drug
Neutropenia
030106 microbiology
MESH: Antifungal Agents/therapeutic use
stem cell transplantation
MESH: Fluconazole/administration & dosage
MESH: Thalidomide/adverse effects
MESH: Fluconazole/therapeutic use
MESH: Candida albicans/isolation & purification
03 medical and health sciences
Immune system
Refractory
Immune reconstitution inflammatory syndrome
MESH: Hodgkin Disease/complications
MESH: Immune Reconstitution Inflammatory Syndrome/immunology
medicine
Humans
Transplantation
Homologous
Autologous transplantation
Glucocorticoids
MESH: Immune Reconstitution Inflammatory Syndrome/diagnostic imaging
Transplantation
MESH: Humans
business.industry
MESH: Chronic Disease
medicine.disease
immune reconstitution inflammatory syndrome
MESH: Male
MESH: Recurrence
MESH: Immune Reconstitution Inflammatory Syndrome/drug therapy
MESH: Immunosuppressive Agents/adverse effects
MESH: Thalidomide/therapeutic use
Chronic Disease
MESH: Hodgkin Disease/surgery
Immunology
MESH: Positron Emission Tomography Computed Tomography
business
Zdroj: Transplant Infectious Disease
Transplant Infectious Disease, Wiley, 2017, 19 (1), pp.e12637. ⟨10.1111/tid.12637⟩
Transplant Infectious Disease, 2017, 19 (1), pp.e12637. ⟨10.1111/tid.12637⟩
ISSN: 1398-2273
1399-3062
DOI: 10.1111/tid.12637
Popis: International audience; Chronic disseminated candidiasis (CDC) is a rare and difficult‐to‐treat invasive fungal disease occurring mainly after prolonged and profound neutropenia. We describe the case of a 59‐year‐old man successfully treated with thalidomide for CDC recurrences after an autologous transplantation. We add evidence of the effectiveness of immunomodulatory drugs to manage inflammatory reconstitution immune syndrome‐related refractory CDC.
Databáze: OpenAIRE
Externí odkaz: