The relationship between asymptomatic organ damage, and serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and Interleukin-17A (IL-17A) levels in non-diabetic hypertensive patients
| Autor: | Canan Topcuoglu, A Nurdan Barca, Serdar Akyel, Fatih Dede, Fatma Akyel, Nihal Ozkayar, Ihsan Ates |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty Systole Diastole Hypertensive Retinopathy Carotid Intima-Media Thickness Gastroenterology Asymptomatic Hypertensive retinopathy Risk Factors Internal medicine medicine Albuminuria Humans Antihypertensive Agents Aged Tumor necrosis factor-like weak inducer of apoptosis Proteinuria Asymptomatic organ damage business.industry Interleukin-17 Cytokine TWEAK Organ Size Middle Aged medicine.disease Endocrinology Blood pressure ROC Curve Intima-media thickness Nephrology Asymptomatic Diseases Hypertension Tumor Necrosis Factors Disease Progression Female Hypertrophy Left Ventricular Microalbuminuria medicine.symptom business Research Article |
| Zdroj: | BMC Nephrology |
| ISSN: | 1471-2369 |
| DOI: | 10.1186/1471-2369-15-159 |
| Popis: | Background This study aimed to measure the serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin-17A (IL-17A) levels in hypertensive patients with/without asymptomatic organ damage (AOD), as well as to determine the relationship between the serum sTWEAK and IL17-A levels, and carotid intima media thickness (CIMT), proteinuria, retinopathy, and the left ventricle mass index (LVMI). Methods The study included 159 patients diagnosed with and followed-up for primary hypertension (HT); 79 of the patients had AOD (61 female and 18 male) and 80 did not (52 female and 28 male). sTWEAK and IL-17A levels were measured in all patients. Results The sTWEAK level was significantly lower in the patients with AOD than in those without AOD (858.4 pg/mL vs. 1151.58 pg/mL, P = 0.001). The sTWEAK level was negatively correlated with the mean microalbuminuria level and LVMI. The median IL-17A level was significantly higher in the patients with AOD than in those without AOD (2.34 pg/mL vs. 1.80 pg/mL, P = 0.001). There was a positive correlation between mean IL-17A level, and mean microalbuminuria level, CIMT, and LVMI. Multivariate logistic regression analysis showed that patient age, sTWEAK level, and mean 24-h systolic blood pressure were predictors of AOD. Conclusions The sTWEAK level was lower and IL-17A level was higher in the patients with AOD. It remains unknown if sTWEAK and IL-17A play a role in the pathophysiology of AOD. Prospective observational studies are needed to determine the precise role of sTWEAK and IL-17A in the development of target organ damage. |
| Databáze: | OpenAIRE |
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