Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy
| Autor: | Peter Kruzliak, Sandeep Saxena, Jana Stefanickova, Shashi Kumar Bhasker, Abbas Ali Mahdi, Dwividendra Kumar Nim, Jela Valaskova, Ankita, Kaleem Ahmad, Apjit Kaur |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Tertiary care chemistry.chemical_compound Hba1c level Ophthalmology medicine Humans In patient Aged Glycated Hemoglobin Analysis of Variance Diabetic Retinopathy business.industry Patient data Diabetic retinopathy Middle Aged medicine.disease Cross-Sectional Studies chemistry Case-Control Studies Hyperglycemia Ionic calcium Standard protocol Calcium Female Glycated hemoglobin business Photoreceptor Cells Vertebrate |
| Zdroj: | International ophthalmology. 39(10) |
| ISSN: | 1573-2630 |
| Popis: | To study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR).This is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c 7, n = 26) and group 2 (HbA1c 7, n = 37). Data were analyzed statistically.Mean ionic calcium levels in group 1 and group 2 were 1.131 ± 0.073 mmol/dL and 1.170 ± 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p = 0.01) in group 2 cases.Increased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c 7 in DR. |
| Databáze: | OpenAIRE |
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