Reductions of Circulating Nitric Oxide are Followed by Hypertension during Pregnancy and Increased Activity of Matrix Metalloproteinases-2 and -9 in Rats

Autor: Elen Rizzi, Regina Aparecida Nascimento, Jose Sergio Possomato-Vieira, Carlos A. Dias-Junior, Giselle F Bonacio
Přispěvatelé: Universidade Estadual Paulista (Unesp), UNAERP
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
medicine.medical_specialty
Pregnancy Complications
Cardiovascular
Uterus
Blood Pressure
Gestational Age
030204 cardiovascular system & hematology
Matrix metalloproteinase
medicine.disease_cause
Article
metalloproteinases
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
nitric oxide
medicine.artery
Internal medicine
Placenta
medicine
Animals
lcsh:QH301-705.5
Aorta
business.industry
General Medicine
Lipid Metabolism
medicine.disease
Enzyme Activation
rats
Oxidative Stress
NG-Nitroarginine Methyl Ester
030104 developmental biology
medicine.anatomical_structure
Blood pressure
Endocrinology
Matrix Metalloproteinase 9
chemistry
lcsh:Biology (General)
Hypertension
Matrix Metalloproteinase 2
hypertensive pregnancy
Female
Lipid Peroxidation
business
Biomarkers
Oxidative stress
Zdroj: Cells, Vol 8, Iss 11, p 1402 (2019)
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Cells
Volume 8
Issue 11
ISSN: 2073-4409
Popis: Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, placenta, uterus and aorta, NO bioavailability, oxidative stress, systolic blood pressure (SBP), and fetal-placental development at the early, middle, and late pregnancy stages in normotensive and N&omega
Nitro-L-arginine methyl-ester (L-NAME)-induced hypertensive pregnancy in rats. Reduced MMP-2 activity in uterus, placenta, and aorta and reduced MMP-9 activity in plasma and placenta with concomitant increased NO levels were found in normotensive pregnant rats. By contrast, increased MMP-2 activity in uterus, placenta, and aorta, and increased MMP-9 activity in plasma and placenta with concomitant reduced NO levels were observed in hypertensive pregnant rats. Also, elevated oxidative stress was displayed by hypertensive pregnant rats at the middle and late stages. These findings in the L-NAME-treated pregnant rats were also followed by increases in SBP and associated with fetal growth restrictions at the middle and late pregnancy stages. We concluded that NO bioavailability may regulate MMPs activation during normal and hypertensive pregnancy.
Databáze: OpenAIRE
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