Reductions of Circulating Nitric Oxide are Followed by Hypertension during Pregnancy and Increased Activity of Matrix Metalloproteinases-2 and -9 in Rats
Autor: | Elen Rizzi, Regina Aparecida Nascimento, Jose Sergio Possomato-Vieira, Carlos A. Dias-Junior, Giselle F Bonacio |
---|---|
Přispěvatelé: | Universidade Estadual Paulista (Unesp), UNAERP |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Pregnancy Complications Cardiovascular Uterus Blood Pressure Gestational Age 030204 cardiovascular system & hematology Matrix metalloproteinase medicine.disease_cause Article metalloproteinases Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy nitric oxide medicine.artery Internal medicine Placenta medicine Animals lcsh:QH301-705.5 Aorta business.industry General Medicine Lipid Metabolism medicine.disease Enzyme Activation rats Oxidative Stress NG-Nitroarginine Methyl Ester 030104 developmental biology medicine.anatomical_structure Blood pressure Endocrinology Matrix Metalloproteinase 9 chemistry lcsh:Biology (General) Hypertension Matrix Metalloproteinase 2 hypertensive pregnancy Female Lipid Peroxidation business Biomarkers Oxidative stress |
Zdroj: | Cells, Vol 8, Iss 11, p 1402 (2019) Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Cells Volume 8 Issue 11 |
ISSN: | 2073-4409 |
Popis: | Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, placenta, uterus and aorta, NO bioavailability, oxidative stress, systolic blood pressure (SBP), and fetal-placental development at the early, middle, and late pregnancy stages in normotensive and N&omega Nitro-L-arginine methyl-ester (L-NAME)-induced hypertensive pregnancy in rats. Reduced MMP-2 activity in uterus, placenta, and aorta and reduced MMP-9 activity in plasma and placenta with concomitant increased NO levels were found in normotensive pregnant rats. By contrast, increased MMP-2 activity in uterus, placenta, and aorta, and increased MMP-9 activity in plasma and placenta with concomitant reduced NO levels were observed in hypertensive pregnant rats. Also, elevated oxidative stress was displayed by hypertensive pregnant rats at the middle and late stages. These findings in the L-NAME-treated pregnant rats were also followed by increases in SBP and associated with fetal growth restrictions at the middle and late pregnancy stages. We concluded that NO bioavailability may regulate MMPs activation during normal and hypertensive pregnancy. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |