Assessing whole brain perfusion changes in patients with REM sleep behavior disorder
| Autor: | Jean-Paul Soucy, Stéphanie Mazza, Paul Gravel, Martin Michaud, Jacques Montplaisir, Jessica Massicotte-Marquez, Anne Décary, Ronald B. Postuma |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Polysomnography Rapid eye movement sleep Perfusion scanning REM Sleep Behavior Disorder Neurological disorder REM sleep behavior disorder Predictive Value of Tests Internal medicine medicine Humans Cysteine Cerebral perfusion pressure Aged Cerebral Cortex Tomography Emission-Computed Single-Photon Putamen Brain Neurodegenerative Diseases Parkinson Disease Organotechnetium Compounds Cerebral Arteries Middle Aged Prognosis medicine.disease Corpus Striatum Cerebral blood flow Cerebrovascular Circulation Anesthesia Cardiology Female Neurology (clinical) Psychology Brain Stem Brodmann area |
| Zdroj: | Neurology. 67:1618-1622 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/01.wnl.0000242879.39415.49 |
| Popis: | Objective: To investigate the regional cerebral perfusion in patients with idiopathic REM behavior disorder (RBD) in order to establish the topography of networks involved. Methods: We performed cerebral blood flow evaluation using 99m Tc-Ethylene Cysteinate Dimer (ECD) SPECT on eight patients with polysomnographically confirmed RBD and nine age-matched controls. Comparisons were made using SPM2. Results: We found increased perfusion in the pons and putamen bilaterally and in the right hippocampus. In addition, we observed a decreased perfusion in frontal (Brodmann area [BA] 4, 6, 10, 43, 44, 47 bilaterally and left BA 9, 46) and temporo-parietal (BA 13, 22, 43 bilaterally and left BA 7, 19, 20, 21, 39, 40, 41, 42) cortices. Conclusion: Perfusional abnormalities in patients with REM behavior disorder were located in the brainstem, striatum, and cortex. These abnormalities are consistent with the anatomic metabolic profile of Parkinson disease. |
| Databáze: | OpenAIRE |
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