Electrokinetic and Hemostatic Profiles of Nonwoven Cellulosic/Synthetic Fiber Blends with Unbleached Cotton
| Autor: | Alvin F. Bopp, Elena Graves, Brian Condon, J. Vincent Edwards, Michael Santiago, Nicolette T. Prevost |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
lcsh:Biotechnology
Biomedical Engineering electrokinetic properties Fibrin Article Biomaterials Contact angle chemistry.chemical_compound lcsh:TP248.13-248.65 medicine Viscose Fiber Composite material contact angle Polypropylene lcsh:R5-920 biology Chemistry thromboelastography accelerated clotting Polyester Synthetic fiber biology.protein hemostasis nonwoven cotton Swelling medicine.symptom lcsh:Medicine (General) circulatory and respiratory physiology |
| Zdroj: | Journal of Functional Biomaterials, Vol 5, Iss 4, Pp 273-287 (2014) Journal of Functional Biomaterials Volume 5 Issue 4 Pages 273-287 |
| ISSN: | 2079-4983 |
| Popis: | Greige cotton contains waxes and pectin on the outer surface of the fiber that are removed when bleached, but these components present potential wound dressing functionality. Cotton nonwovens blended with hydrophobic and hydrophilic fibers including viscose, polyester, and polypropylene were assessed for clotting activity with thromboelastography (TEG) and thrombin production. Clotting was evaluated based on TEG measurements: R (time to initiation of clot formation), K (time from end of R to a 20 mm clot), α (rate of clot formation according to the angle tangent to the curve as K is reached), and MA (clot strength). TEG values correlate to material surface polarity as measured with electrokinetic parameters (ζplateau, Δζ and swell ratio). The material surface polarity (ζplateau) varied from −22 to −61 mV. K values and thrombin concentrations were found to be inversely proportional to ζplateau with an increase in material hydrophobicity. An increase in the swell ratios of the materials correlated with decreased K values suggesting that clotting rates following fibrin formation increase with increasing material surface area due to swelling. Clot strength (MA) also increased with material hydrophobicity. Structure/function implications from the observed clotting physiology induced by the materials are discussed. |
| Databáze: | OpenAIRE |
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