Complex Interaction of a2-Adrenoceptor Binding Sites with Bovine Brain and Lung Extracts Containing Clonidine-Displacing Substance
| Autor: | V. G. Wilson, Darawan Pinthong, David A. Kendall |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Brain Chemistry
Binding Sites Lung Adrenergic receptor Tissue Extracts Chemistry Methanol General Neuroscience Clonidine-displacing substance Alpha (ethology) Pharmacology Clonidine General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound medicine.anatomical_structure History and Philosophy of Science Bovine brain Receptors Adrenergic alpha-2 medicine Animals Potency Cattle Binding site Histamine |
| Zdroj: | Annals of the New York Academy of Sciences. 1009:216-221 |
| ISSN: | 0077-8923 |
| Popis: | Previous studies have established that methanolic extracts of bovine brain and lung possess CDS activity with an agonist-like profile at alpha(2)-adrenoceptor binding sites (i.e., greater potency against [(3)H]-clonidine sites than against [(3)H]-RX-821001 sites). Following prolonged reflux in ethylacetate, monovalent cations and histamine were removed from the lung extract, and the resulting extract exhibited similar potency against both radioligands, indicative of an antagonist-like profile. These observations help explain the absence of biologic activity at alpha(2)-adrenoceptors in the methanolic extracts as reported in our companion paper. |
| Databáze: | OpenAIRE |
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