Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein
| Autor: | Dimitrios Karamichos, Jesper Hjortdal, Sashia Bak-Nielsen, Rabab Sharif |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Keratoconus media_common.quotation_subject Disease Models Biological Article Pathogenesis Cornea 03 medical and health sciences 0302 clinical medicine Internal medicine Prolactin-induced protein medicine Humans Menstrual cycle media_common Glycoproteins business.industry Corneal Diseases Membrane Transport Proteins medicine.disease Sensory Systems Ophthalmology 030104 developmental biology Endocrinology 030221 ophthalmology & optometry Biomarker (medicine) business Carrier Proteins Biomarkers Hormone |
| Zdroj: | Sharif, R, Bak-Nielsen, S, Hjortdal, J & Karamichos, D 2018, ' Pathogenesis of Keratoconus : The intriguing therapeutic potential of Prolactin-inducible protein ', Progress in Retinal and Eye Research, vol. 67, pp. 150-167 . https://doi.org/10.1016/j.preteyeres.2018.05.002 |
| ISSN: | 1873-1635 |
| DOI: | 10.1016/j.preteyeres.2018.05.002 |
| Popis: | Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered. Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea. Hormone levels have been reported to alter corneal thickness, curvature, and sensitivity during different times of menstrual cycle. Surprisingly, the role of sex hormones in corneal diseases and KC has been largely neglected. Prolactin-induced protein, known to be regulated by sex hormones, is a new KC biomarker that has been recently proposed. Studies herein discuss the role of sex hormones as a control mechanism for KC onset and progression and evidence supporting the view that prolactin-induced protein is an important hormonally regulated biomarker in KC is discussed. |
| Databáze: | OpenAIRE |
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