Dehydration is a strong predictor of long-term prognosis of thrombolysed patients with acute ischemic stroke

Autor: Hui-Sheng Chen, Sha-Sha Li, Zhong-He Zhou, Ming-Ming Yin
Rok vydání: 2016
Předmět:
TOAST Classification
Blood Glucose
Male
medicine.medical_specialty
thrombolysis
medicine.medical_treatment
Blood Pressure
030204 cardiovascular system & hematology
Fibrinogen
blood urea nitrogen/creatinine
Blood Urea Nitrogen
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
urine specific gravity
Modified Rankin Scale
Risk Factors
Internal medicine
Hyperlipidemia
medicine
ischemic stroke
Humans
Thrombolytic Therapy
cardiovascular diseases
Prospective Studies
Risk factor
Intensive care medicine
Aged
Original Research
Dehydration
business.industry
Urine specific gravity
Thrombolysis
Cerebral Infarction
medicine.disease
Creatine
Prognosis
Recombinant Proteins
Blood pressure
Tissue Plasminogen Activator
Acute Disease
Cardiology
Female
business
030217 neurology & neurosurgery
medicine.drug
Follow-Up Studies
Zdroj: Brain and Behavior
ISSN: 2162-3279
Popis: Background and Purpose Dehydration was found to be involved in the poor prognosis of patients with acute ischemic stroke. It is unclear whether dehydration status before onset is related with prognosis of thrombolysed patients with acute ischemic stroke. If it is the case, quickly hydrating may improve the prognosis. The present study was designed to explore the issue. Methods Eligible 294 patients with acute ischemic stroke after thrombolysis were enrolled in the present study according to inclusion/exclusion criteria. According to the modified Rankin scale (mRS) 90 days post stroke, the patients were divided into two groups: mRS 0–2 (n = 191) and mRS 3–6 (n = 103). In the present study, BUN/Cr ≥ 15 combined with USG > 1.010 or either of them were chosen as dehydration marker. Clinical data were analyzed between two groups. Univariate and multivariate statistical analyses were carried out. Results Age, fibrinogen, blood glucose, BUN/Cr, NIHSS score at admission, the systolic blood pressure (SBP) before thrombolysis, dehydration status (BUN/Cr ≥ 15 plus USG > 1.010), hyperlipidemia, USG and D‐dimer on admission day, and TOAST classification showed significant difference between two groups (p 150 were markedly associated with poor outcome (mRS 3–6, p 1.010 as a marker of dehydration status was an independent risk factor for long‐term poor prognosis of thrombolysed patients with acute ischemic stroke.
Databáze: OpenAIRE
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