Correlation of Tc-99m GSA Hepatic Studies With Biopsies in Patients With Chronic Active Hepatitis
| Autor: | SEIJI TOMIGUCHI, TOMOHIRO KIRA, YOICHI OYAMA, MITSUKO NABESHIMA, RUMI NAKASHIMA, AKINORI TSUJI, AKIHIRO KOJIMA, MUTSUMASA TAKAHASHI, SHUNJI YOSHIMATSU, KATSURO SAGARA, RYOICHI KURANO |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Necrosis Biopsy chemistry.chemical_element Technetium Scintigraphy Hepatitis Fibrosis medicine Humans Radiology Nuclear Medicine and imaging Radionuclide Imaging Technetium Tc 99m Aggregated Albumin Aged medicine.diagnostic_test Chronic Active business.industry General Medicine Middle Aged medicine.disease Liver chemistry Chronic Disease Technetium Tc 99m Pentetate Female medicine.symptom Hepatic fibrosis business |
| Zdroj: | Clinical Nuclear Medicine. 20:717-720 |
| ISSN: | 0363-9762 |
| Popis: | To determine whether scintigraphic findings of Tc-99m DTPA-galactosyl-HSA (GSA) correspond to histopathologic findings, Tc-99m GSA hepatic scintigraphy and biopsy were compared in 65 patients with chronic active hepatitis. After injecting 185 MBq of Tc-99m GSA, anterior images were obtained at 5 minutes and 15 minutes. Scintigrams were classified into three grades according to the extent of visualization of the cardiac blood pool on 5 minute and 15 minute images. Biopsies were subjectively graded for findings of necrosis and fibrosis. Scintigraphic grades on 5 minute images were correlated with hepatic necrosis and fibrosis and those on 15-minute images with hepatic fibrosis. Scintigraphic abnormalities of Tc-99m GSA correlated well with histopathologic abnormalities, especially with hepatic fibrosis and necrosis in patients with chronic active hepatitis. |
| Databáze: | OpenAIRE |
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