Replication of the association of GLT6D1 with aggressive periodontitis in a Sudanese population
| Autor: | Gerard J. Linden, Ikhlas El Karim, N.T. Hashim, Bakri G. Gismalla, M.E. Ibrahim, Fionnuala Lundy, Francis J. Hughes |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Candidate gene Genotype Population Alveolar Bone Loss HapMap Project Polymorphism Single Nucleotide Sudan Young Adult Gene Frequency Internal medicine Periodontal Attachment Loss medicine Humans Aggressive periodontitis International HapMap Project education Gene Genotyping Genetic Association Studies Genetics education.field_of_study business.industry Genetic Variation Glycosyltransferases medicine.disease Minor allele frequency Aggressive Periodontitis Case-Control Studies Periodontics Female Gene polymorphism business |
| Zdroj: | Hashim, N T, Linden, G J, Ibrahim, M E, Gismalla, B G, Lundy, F T, Hughes, F J & El Karim, I A 2015, ' Replication of the association of GLT6D1 with aggressive periodontitis in a Sudanese population ', Journal of Clinical Periodontology, vol. 42, no. 4, pp. 319-324 . https://doi.org/10.1111/jcpe.12375 |
| DOI: | 10.1111/jcpe.12375 |
| Popis: | BACKGROUND: Susceptibility to aggressive periodontitis (AgP) is influenced by genetic as well as environmental factors. Studies linking gene variants to AgP have been mainly centred in developed countries with limited data from Africa.AIM: To investigate whether previously reported candidate gene associations with AgP could be replicated in a population from Sudan.METHODS: The investigation was a case-control design. Cases with AgP (n = 132) and controls (n = 136) were identified from patients attending the Periodontal Department in Khartoum Dental Hospital. Genotyping was performed using the Sequenom MassARRAY iPLEX platform. Analysis focused on gene variants with a minor allele frequency (MAF) > 25% in the Sudanese subjects that had previously been reported to be associated with AgP.RESULTS: One candidate gene rs1537415 (GLT6D1) was significantly associated with AgP, OR = 1.50 (95% CI 1.04-2.17), p = 0.0295 (increasing to p = 0.09 after correction for multiple testing). The association strengthened to OR = 1.56 (95% CI 1.15-2.16), p = 0.0042 when the controls were supplemented with data from the Hap map for the Yoruba in Ibadan (n = 147) and remained significant (p = 0.013) after correction for multiple testing.CONCLUSION: The study independently replicated the finding that rs1537415, a variant in glycosyl transferase gene GLT6D1, is associated with AgP and provided the first report of genetic associations with AgP in a Sudanese population. |
| Databáze: | OpenAIRE |
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