Suppression of liver Apo E secretion leads to HDL /cholesterol immaturity in rats administered ethinylestradiol
| Autor: | Mariko Ishii, Naoyuki Maeda, Hiroshi Yokota, Kosuke Yamaguchi, Hidetomo Iwano |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Apolipoprotein E medicine.medical_specialty HDL medicine.medical_treatment Diethylstilbestrol Apo E General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound Ethinylestradiol Internal medicine medicine Research Articles endocrine disruptor Cholesterol cholesterol 030104 developmental biology Endocrinology chemistry Toxicity ethinylestradiol diethylstilbestrol lipids (amino acids peptides and proteins) Combined oral contraceptive pill Tamoxifen Research Article Lipoprotein medicine.drug |
| Zdroj: | FEBS Open Bio |
| ISSN: | 2211-5463 |
| Popis: | Ethinylestradiol (EE), a main component of the combined oral contraceptive pill, is associated with an increased risk of arterial diseases. However, the toxicity mechanism of EE is poorly understood. In this study, we found that the exposure to EE reduced the serum apolipoprotein E (Apo E) level and high-density lipoprotein (HDL)/cholesterol concentration in adult female rats. Diethylstilbestrol showed the same effects and both reductions were suppressed by coadministration of tamoxifen (TAM). Liver perfusion experiments revealed that the secretion rate of Apo E from the liver was significantly reduced. It is concluded that EE damages the maturation of HDL/cholesterol by delaying Apo E secretion from the liver, and this may lead to an increased risk of arterial diseases, such as atheromas. |
| Databáze: | OpenAIRE |
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