Continuous infusion of high-dose acyclovir for serious herpesvirus infections
| Autor: | Bonnie Bean, Courtney V. Fletcher, Janet A. Englund, Barbara J. Chinnock, Henry H. Balfour, D. M. Brundage |
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| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Continuous infusion medicine.medical_treatment Acyclovir medicine.disease_cause Herpesviridae Pharmacokinetics Alphaherpesvirinae Medicine Humans Pharmacology (medical) Aciclovir Child Infusions Intravenous Pharmacology Chemotherapy biology business.industry Infant Liter Herpesviridae Infections biology.organism_classification Surgery Infectious Diseases Anesthesia Child Preschool Female Viral disease business medicine.drug Research Article |
| Popis: | Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 mumol/liter. Of 12 patients who had continuous infusion for greater than 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy. |
| Databáze: | OpenAIRE |
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